卵巢黏液性腺癌106例临床分析

Clinical Analysis of 106 Cases with Ovarian Mucinous Adenocarcinoma

[目的]探讨与卵巢黏液性腺癌预后可能的相关因素。[方法]回顾性分析中山大学肿瘤防治中心妇科收治的106例卵巢黏液性腺癌病例资料。[结果]106例患者的5年、10年生存率分别为67.0%和59.0%。单因素分析显示,FIGO分期、手术是否能达到满意肿瘤细胞减灭术、合并卵巢腺瘤或交界瘤病史、淋巴结病理、腹水病理是卵巢黏液性腺癌患者预后的影响因素;而多因素分析显示,FIGO分期和是否达到满意肿瘤细胞减灭术是其独立预后因素。[结论]对于卵巢黏液性腺癌,FIGO分期、手术是否能达到满意肿瘤细胞减灭术是影响预后的独立因素。卵巢黏液性腺癌治疗的首要方法是手术治疗。对于早期需保留生育功能的患者,可行保守性手术。对于晚期患者,应尽量达到满意肿瘤细胞减灭术。

[Purpose] To investigate the factors related to prognosis of ovarian mucinous ade- nocarcinoma. [Methods] The clinical data of 106 cases with ovarian mucinous adenocarci- noma in gynecologic department of Sun Yat-sen University Cancer Center were reviewed. [Results] The overall 5- and lO-year survival rates were 67.0% and 59.0%, respectively. Univariate analysis showed that FIGO stage, optimal cytoreductive surgery, complicated with ovarian adenoma or borderline ovarian tumor, lymph node metastasis and ascites were the factors which affecting prognosis. Multivariate analysis showed that FIGO stage and op- timal cytoreductive surgery were the independent prognostic factors which affecting progno- sis. [Conclusion] FIGO stage and optimal cytoreductive surgery are the independent prog- nostic factors for ovarian mucinous adenocarcinoma. Surgery is the first choice for ovarian mucinous adenoearcinoma. In young patients with early stage and desirous to preserve fer- tility, conservative surgery may be performed. In patients with advanced stage, optimal cy- toreduetive surgery should be performed as possible..