急性脑梗死患者血清S100蛋白B及胶质纤维酸性蛋白的变化及其临床意义

The serum consentration change rules of S100B/GFAP in patients with acute ischemic stroke

目的研究S100蛋白B（S100B）、胶质纤维酸性蛋白（GFAP）在急性脑梗死患者不同病程时期的水平变化规律，分析其在疾病发生发展中的临床意义。方法检测急性发病不超过24小时的脑梗死患者不同时期血清中S100B、GFAP的水平变化，结合神经功能缺失程度，并通过前后自身对照，分析S100B、GFAP在疾病发生发展中的意义。结果急性缺血性脑梗死患者血清中S100B、GFAP明显高于对照组。最初24小时内S100B的水平与第3-5天、7-10天神经功能缺失程度显著相关。结论S100B水平与神经功能缺失程度相关，其在发病后24小时内的血清浓度可提示之后的神经功能缺损。S100B可作为监测急性脑梗死预后的标记物。

Objective To explore the serum consentration changes of S-100 protein B （SIOOB） and gelatinous fiber acidic protein（GFAP） in patients with acute ischemic stroke ,analyse the significance in the occurrence and development of disease. Methods The kinetics of S100B and GFAP were analysed in different courses of disease in the acute cerebral infarction patients whose diseases onset did not exceed 24 hours. Serial venous blood samples were taken within 24 h and the 3-5 days ,7-10 days after stroke on- set. The neurological deficit was quantified by the National Institute of Healthy stroke scale score at the same time. Results SIOOB and GFAP of patients with acute ischemic stroke showed significantly higher than healthy controls （P 〈 O. 05 ）. The release of S100B was highly correlated with the severity of the neu- rological deficit on the 3-5 days and 7-10 days after stroke onset. Conclusion The serum concentration of SIOOB was associated with the severity in neurological deficit. The serum concentrations within 24h after stroke onset indicate the neurological deficit thereafter. S100B may serve as a monitoring parameter in acute ischemic stroke.