三维适形放疗联合同步化疗对局部进展期胃癌患者手术后疗效的分析

Clinical study of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for postoperative locally advanced gastric cancer

目的探讨局部进展期胃癌术后应用三维适形放疗(3D-CRT)联合XELOX方案化疗的临床疗效。方法回顾分析68例局部进展期胃癌D2切除术后患者,根据不同治疗方案分为观察组(32例)给予3D-CRT联合XELOX方案化疗;对照组(36例)仅给予XELOX方案化疗。比较两组的近期疗效、远期生存率和不良反应发生率的差异。结果观察组患者的症状控制率、完全缓解率和总有效率明显高于对照组(P<0.05),观察组的1年、2年生存率以及中位生存时间明显较高(P<0.05),观察组的骨髓抑制及胃肠道反应的发生率明显高于对照组(P<0.05)。结论局部进展期胃癌术后应用3D-CRT联合XELOX方案化疗可提高近期疗效及远期生存状况,但不良反应的发生率高。

Objective To analyze the curative effect of three-dimensional conformal radiotherapy （3D-CRT） combined with concurrent XELOX program chemotherapy for postoperative locally advanced gas- tric cancer. Methods A total of 68 patients received D2 resection for locally advanced gastric cancer were taken retrospective analyses and divided into two groups, observation group （received 3D-CRT combined with XELOX program chemotherapy, 32 cases ）and control group （received XELOX program chemotherapy only, 36 cases） , according to therapeutic regimen. The short-term efficacy, long-term survival rate and ad- verse reactions rate were compared between two groups. Results Compared to control group, the control rate of symptoms, the complete remission rate and total effective rate in observation group were higher（ P 〈 0. 05 ）, and the 1,2-year survival rates and the median survival rate in observation group were higher（ P 〈 0. 05 ）, but the incidence rates of bone marrow suppression and gastrointestinal tract in observation group were also higher（ P 〈 0. 05 ）. Conclusions The short-term efficacy and long-term survival rate of 3D-CRT combined with XELOX program chemotherapy in the treatment of postoperative locally advanced gastric cancer was perfect, but the adverse reactions increase.