摘要
目的探讨雷替曲塞单药治疗多个方案耐药的复发晚期结直肠癌的疗效和副作用。方法 28例对多个方案耐药的复发晚期结直肠癌患者,给予雷替曲塞3mg/m2,第1天,每21天重复,直到疾病进展为止。结果无有效病例,SD10例,PD18例,肿瘤控制率35.7%,中位肿瘤进展时间(mTTP)2.5个月。不良反应主要是粒细胞减少,I度粒细胞减少为28.6%(8/28),II度粒细胞减少为10.7%(3/28),无化疗相关死亡。结论雷替曲塞单药治疗多药耐药复发的晚期结直肠癌无效,但有一定的肿瘤控制率,毒性可以耐受。
Objective To observe the efficacy and side effects of heavily pretreated recurrenced and advanced colorectal carcinoma （CRC） which treated by rahitrexed. Methods Twenty-eight patients with recurrenced and advanced CRC were treated by raltitrexed 3 mg/m2, on dl, repeated every 21 days, until the progression disease. Results There was no response patients, 10 patients achieved a stable dis- ease（ SD）, 18 patients achieved a progress disease（PD） and the disease control rate（DCR） was 35.7%, and the median time to progression（mTFP） was 2. 5 months. The major adverse effects was marrow depres- sion and 28.6% （8/28） of patients with grade Ⅰ granulocytopenia and 10. 7% （3/28） of patients with grade Ⅱ granulocytopenia. There was no chemotherapy related death. Conclusions There was no effectiveness on heavily pretreated recurrenced and advanced CRC which treated by raltitrexed, but there was a mild DCR and the side effects were well tolerance.
出处
《中国肿瘤临床与康复》
2013年第2期177-178,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
结直肠肿瘤
药物疗法
雷替曲塞
Colorectal neoplasms
Drug therapy
Raltitrexed
