药学干预前后我院Ⅰ类切口手术预防用抗菌药比较

Comparison of the Application of Preventive Antibiotics for TypeⅠIncision Operation before and after Pharmaceutical Interference

目的:评价我院临床药师干预前、后Ⅰ类切口手术围术期抗菌药的应用情况与效果比较。方法:对我院2010年7～12月和2011年7～12月Ⅰ类切口手术预防用抗菌药的使用率、应用种类与频次、给药时机、用药时限、费用等进行统计分析。结果:实施药学干预后,我院Ⅰ类切口手术预防用抗菌药使用率由100%降至48.33%,第1代头孢菌素应用率由0升至63.79%;术前0.5～2 h预防用抗菌药比例由17.92%提高至95.59%;术后用抗菌药时间≤24 h的比例由23.33%提高至81.03%;平均用药时间由4.5 d缩短至1.9 d;平均抗菌药费用由635.69元降至256.57元。结论:实施药学干预可显著提高围术期抗菌药合理应用,对合理使用抗菌药有积极促进作用。

Objective：To evaluate the application and effects of antibiotics used before and after pharmaceutical interference by clinical pharmacists during the preoperative period of type I incision operation. Methods：The patients＇ statistics, varieties, frequency, time of drug delivery, administration duration and antibiotics expenses were gathered and analyzed for their type I incision operations from July to December of 2010 and from July to December of 2011. Results： After the pharmaceutical interference, the cephalosporin （first generation） used in our hospital was increased from 0 to 63.79%. The ratio covered by the preventive antibiotics that were used O. 5 to 2 hours before the operation was increased from 17.92% to 95.59%. The ratio for the duration not more than 24 hours of antibiotics administration was increased from 23.33% to 81.03%. The average drug administration time was shortened from 4.5 days to 1.9 days. The average expense for antibiotics was decreased from 635.69 yuan to 256.57 yuan. Conclusion：The implementation of pharmaceutical inter- ference could significantly facilitatethe reasonable application of antibiotics during the preoperative period, thus boosting the safe, effective, reasonable and economic administration of drug for patients.