微管蛋白和肝肠钙粘连蛋白在胃腺癌中的表达及相关性分析

Analysis of cliniai features correlated with the expression of Tubulin β-2C and LI-cadherin in gastric adenocarcinoma

目的探讨微管蛋白（Tubulin β-2c）和肝肠钙粘连蛋白（LI-cadherin）在胃腺癌组织中表达的临床意义及两种蛋白的相关性。方法应用免疫组化S-P法，检测Tubulin β-2C及LI-cadherin在60例胃腺癌组织中的表达，并分析两种蛋白的相关性。结果Tubulin β2C及LI—cadherin在胃腺癌组织中的阳性表达率分别为73．33％和68．33％，在癌旁及正常组织中均不表达，两种蛋白的表达呈正相关（r=0．450，P〈0．05）。Tubulin β-2C与肿瘤分化程度有关，与年龄、性别以及淋巴结转移无关。LI—cadherin与肿瘤浸润程度及淋巴结转移有关（P〈0．05），与性别、年龄无关。结论Tubulin β-2c是胃腺癌发生发展过程中一种重要的蛋白分子，其表达强度与胃腺癌分化程度有关，且与LI—cadherin的表达呈正相关。

Objective To investigate the expression of Tubulin β-2C and LI-cadherin in gastric adenocarcinoma and verify the correlation between them. Methods Immunohistochemically staining of Tubulin β-2C and LI-cadherin were tested in 60 patients with gastric carcinoma. Results The positive rates of Tubulin β-2C. and LI-cadherin were 73.33% and 68.33% respectively in gastric carcinoma,and no expression in normal and adjacent tissues. The expression of Tubulin β-2C was related to differentiation degree of tumors instead of sex, age and TNM stages. There was a positive correlation between Tubulin β-2Cand LI-cadherin（r = 0. 450,P 〈 0. 05 ）. Conclusion Expressive intensity of Tubulin β-2C is strong and related to LI-cadherin. They play an important role in the pathogenesis and development of gastric adenocarcinoma.