期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

热休克蛋白70与2型糖尿病及大血管病变的关系 被引量：3

下载PDF
导出
摘要 据世界卫生组织统计，目前全世界糖尿病患者约有1．8亿人，而2型糖尿病患者占90％。大量研究结果证实，氧化应激及炎症反应等是2型糖尿病及心血管疾病的潜在危险因素。热休克蛋白（Hsp）70家族在生物细胞中含量最高，可诱导性最强，具有多种生物学功能。近年来研究发现Hsp70与2型糖尿病及大血管病有着密切关系。
作者 唐瑶 高萍
机构地区 黑龙江省哈尔滨医科大学附属第二医院内分泌科
出处 《临床内科杂志》 CAS 2013年第2期143-144,共2页 Journal of Clinical Internal Medicine
关键词 热休克蛋白70 2型糖尿病 血管病变 氧化应激
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Calle MC, Femandez ML. Inflammation and type 2 diabetes. Diabetes Metab,2012,38 : 183-191.
  • 2Dzaman-Serafin S, Telatynska-Mieszek B, Ciechanowski K. Heat shockproteins and their characteristics. Pol Merkur Lekarski, 2005, 19: 215-219.
  • 3Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet, 1988, 22 : 631-677.
  • 4Han Z, Truong QA, Park S, et al. Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci USA, 2003, 100: 1256-1261.
  • 5戚筠,杨杨.2型糖尿病患者热休克蛋白70基因多态性的变化[J].临床内科杂志,2011,28(12):842-844. 被引量：6
  • 6Fariss MW, Chan CB, Patel M, et al. Role of mitochondrin in toxic oxi- dative stress. Mol Interv ,2005,5:94-111.
  • 7Nakhjavani M, Morteza A, Khajeali L, et al. Increased serum HSP70 lev- els are associated with the duration of diabetes. Cell Stress Chaperones, 2010,15:959-964.
  • 8Yabunaka N, Ohtsuka Y, Watanabe I, et al. Elevated levels of heat- shock protein 70 (HSP70) in the mononuclear celss of patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract, 1995, 30 : 143-147.
  • 9Nakhjavani M, morteza A, Meysamie A, et al. Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes:does sex matter? Cell Stress Chaperones ,2011,16 : 195-201.
  • 10Kurthy M, Mogyorosi T, Nagy K, et al. Effect of BRX-220 against pe- ripheral neuropathy and insulin resistance in diabetic rat models. Ann N Y Acad Sci ,2002,967:482489.

二级参考文献7

  • 1Bouassida KZ,Chouchane L, Jellouli K. Polymorphism of stress protein HSP70-2 gene in Tunisians : susceptibility implications in type 2 diabe- tes and obesity. Diabetes M etab ,2004,30:175 -180.
  • 2Li JX,Tang BP, Sun HP. Interacting contribution of the five polymor- phisms in three genes of HSPT0 family to essential hypertension in Uygur ethnicity . Cell Stress Chaperones,2009,14:355 - 362.
  • 3Chien V, Aitken JF, Zhang S, et al. The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of 13- sheet-containing aggregates by human amylin : a potential role for defec- tive chaperone biology in Type 2 diabetes. Biochem J, 2010, 432: 113-121.
  • 4Faguer S, Decramer S, Chassaing N, et al. Diagnosis, management, and prognosis of HNF1B nephropathy in adulthood. Kidney Int, 2011,80: 768-776.
  • 5Milner CM, Campbell RD. Genetic organization of the human MHC class 11I region. Front Biosci ,2001,6:914-926.
  • 6Porto I, Leone AM, Crea F, et al. Inflammation, genetics, and ischemic focus on the major histocompatibilitycomplex (MHC) genes. Cytokine, 2005,29 : 187-196.
  • 7Arora P, Garcia-Bailo B, Dastani Z, et al. Genetic polymorphisms of in- nate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. BMC Med Genet,2011,14 ; 12:95.

共引文献5

同被引文献41

  • 1刘茂玲,吴少庭,卢祖洵.2型糖尿病易感基因研究进展[J].中国慢性病预防与控制,2005,13(6):310-312. 被引量：3
  • 2张如锋,王娟,李智滨.脂联素与2型糖尿病大血管病变的相关性研究[J].临床内科杂志,2007,24(2):124-125. 被引量：3
  • 3Zhang X,He M,Cheng L,et al.Elevated heat shock protein 60levels are associated with higher risk of coronary heart disease inChinese[J].Circulation,2008,118(25):2687-2693.
  • 4Shamaei-Tousi A,Stephens JW,Bin R,et al.Association betweenplasma levels of heat shock protein 60 and cardiovascular diseasein patients with diabetes mellitus[J].Eur Heart J,2006,27( 13):1565-1570.
  • 5Hoppichler F,Koch T,Dzien A,et al.Prognostic value of antibodytitre to heat-shock protein 65 on cardiovascular events[J].Cardiology,2000,94(4):220-223.
  • 6Mukheijee M,De Benedictis C,Jewitt D,et al.Association ofantibodies to heat-shock protein-65 with percutaneous transluminalcoronary angioplasty and subsequent restenosis[J].ThrombHaemost,1996,75(2):258-260.
  • 7Huittinen T,Leinonen M,Tenkanen L,et al.Autoimmunity tohuman heat shock protein 60,Chlamydia pneumoniae infection,andinflammation in predicting coronary risk[J].Arterioscler ThrombVase Biol,2002,22(3):431437.
  • 8Bimie DH,Vickers LE,Hillis WS,et al.Increased titres of anti-human heat shock protein 60 predict an adverse one year prognosisin patients with acute cardiac chest pain[J].Heart,2005,91(9):1148-1153.
  • 9Guech-Ongey M,Brenner H,Twardella D,et al.Chlamydiapneumoniae,heat shock proteins 60 and risk of secondarycardiovascular events in patients with coronary heart disease underspecial consideration of diabetes:a prospective study[J].BMCCardiovasc Disord,2006,6:17.
  • 10Esposito P,Tinelli C,Libetta C,et al.Impact of seropositivity toChlamydia pneumoniae and anti-hHSP60 on cardiovascular eventsin hemodialysis patients[J].Cell Stress Chaperones,2011,16(2):219-224.

引证文献3

二级引证文献9

临床内科杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部