细胞因子诱导的杀伤细胞治疗癌症的基础与临床

Foundation and clinic of CIK cell therapy for cancer treatment

近年来,应用细胞因子诱导的杀伤细胞(CIK细胞)进行实体瘤治疗的临床试验在国内外陆续开展,该疗法在临床治疗中表现出明显优于其他过继性免疫治疗手段的强大优势,因而被越来越广泛地被应用到临床肿瘤的过继免疫治疗中。CIK可作为单独的治疗方法,也可与外科手术、放疗、化疗结合进行综合治疗。本文追踪国内外的研究进展,对CIK的来源及表型、活化及扩增、抗肿瘤作用机制、CIK的临床应用、新的技术方法、副作用的处理、疗效评价等诸方面作以简略介绍,对目前治疗当中存在的问题和发展方向等做了有益探索。

In recent years, the clinical test about the application of CIK cells toward solid tumor therapy have been continued carrying out at home and abroad, this therapy showes powerful advantage to be more better than other adoptive immunity treatment during the clinical treatment, therefore it is applied to the adoptive immunity treatment of clinical tumor more and more widely. CIK not only can be used as a separate treatment, but ＇also as comprehensive treatment combined with surgery, radiation therapy, chemotherapy treatment. In this paper, we trace the research progress at home and ＇abroad, to make briefly introductions about the source and phenotype of CIK, activation and amplification, anti-tumor mechanism of action, clinical application of CIK, technical methods and treatment of side effects, evalua- tion of curative effect and so on, and made the beneficial exploration on the current therapy, the existing problems and the development direction and so on.