乳腺癌改良根治术后化疗后相关预后因素分析

Study on the prognostic factors of breast cancer after modified radical mastectomy and chemotherapy

目的探讨影响乳腺癌改良根治术后化疗后相关预后因素并建立预后预测模型。方法选择乳腺癌改良根治术后化疗后资料完整患者96例,收集相关预后因素并进行随访。采用单因素和多因素Cox模型分析,计算预后指数(PI)。结果肿瘤大小、组织病理学类型及腋窝淋巴结转移个数为影响预后的独立因子;由此建立的预后预测模型,具有较高的信度和效度;利用ROC曲线工作原理,当PI≤5.23时,乳腺癌改良根治术后化疗后3年预后结局较好。结论肿瘤大小、组织病理学类型及腋窝淋巴结转移个数为乳腺癌改良根治术后化疗后重要的预后指标,可为临床医师对乳腺癌改良根治术后化疗后患者个体预后结局估计提供有力的工具。

Objective To explore the factors related to the prognosis of breast cancer after modified radical masteetomy and chemotherapy, to establish a prognostic model for evaluating the prognosis of their patients. Methods 96 cases with breast cancer after modified radical masteetomy and chemotherapy were selected in this study and the factors related to the prognosis were collected and followed. Cox regression analysis was used for univariate and multivariate analysis. Prognostic index（PI） was calculated based on the results of multivariate a- nalysis. Results Univariate and multivariate analysis of Cox regression model were the tumor size, histopatho- logical type and number of axillary metastasis lymph nodes. A prognostic model was established. Breast cancer after modified radical mastectomy and chemotherapy had a better three-year outcome with PI ~〈 5.23 by ROC curves. Conclusions Histopathological type and number of axillary metastasis lymph nodes seem to be inde- pendent and important prognostic factors. This prognostic model could be used to evaluate the prognosis of pa- tients with breast cancer after modified radical masteetomy and chemotherapy by clinicians.