甲泼尼龙冲击治疗儿童难治性肾病的临床与病理

Clinic and pathology of methylprednisolone intravenous bolus therapy for child refractory nephrotic syndrome

目的 :探讨小儿难治性肾病的有效治疗措施、疗效与病理类型的关系。 方法 :总结了使用甲泼尼龙冲击治疗的 30例小儿难治性肾病的经验。甲泼尼龙 15～ 30 mg/ ( kg· d) ,共 3天 ,间歇 4～ 7天后用第二个疗程 ,疗程间隙期用泼尼松 1.5～ 2 mg/ ( kg· d)口服 ,疗程结束后 ,泼尼松按中长程疗法治疗。 结果 :30例肾病综合征 14例完全缓解 ,4例部分缓解 ,总有效率为 6 0 % ,无一例出现严重的不良反应。 结论 :甲泼尼龙冲击治疗小儿难治性肾病是一种安全有效的方法 ,特别是对 Ms PGN、MPGN。

Objectives: To probe into an effective therapy and the relation between effect and pathology types. Motheds: Methylprednisolone 15~30 mg/(kg·d) three times a week every other week was given to 30 cases of refractory nephrotic syndrome. Results:Fourteen cases of 30 cases got completely remission, 4 cases got partial remission, and had no severe side reaction. Conclusions: Methylprednisolone is an effective and safe drug for child refractory nephrotic sysdrome, especially for MsPGN,MPGN and MCNS.