载脂蛋白H在肾小管疾病中的研究进展

The advance in the roles of apolipoprotein H in renal tubular disorders

载脂蛋白 H,系人血浆中的一种由 32 6个氨基酸残基组成的单链糖蛋白 ,包括 5个相似的结构域 ,其中富含脯氨酸和半胱氨酸。其理化特性及编码基因特点都己陆续阐明。能激活脂蛋白酯酶 ,从而参与脂类代谢 ,作用于凝血机制 ,抑制血凝 。

Apolipoprotein H(apoH) is isolated from human serum,consisting of 326 amino acid residum and including five repeating units of prolinecysteine rich.The characteristics of its physicschemistry and coding gene was illuminated.apoH can activates lipoproteinase and inhibits coagulation.apoH is an indicator of renal tubular disease.