系统性硬化症心脏损害的临床特点及血管内皮素-1的影响研究

The Impact of the Clinical Features of Systemic Sclerosis,Heart Damage and Vascular Endothelin-1

目的探讨系统性硬化症(SSc)心脏损害的临床特征及血管内皮素-1的影响。方法共101例SSc患者进行甲襞微循环检查及血清血管内皮素-1测定。对45例有心脏损害的SSc临床进行回顾性分析。结果 SSc心脏损害累及瓣膜、心肌、心包、传导系统。SSc合并心脏损害甲襞微循环管襻形态积分、血流状态积分、襻周积分、总积分与SSc无心脏损害组比较明显升高,差异有统计学意义(P<0.05)。并发心脏损害的SSc患者ET-1水平高于无心脏损害者,差异有统计学意义(P<0.05)。结论 SSc伴心脏损害者心电图、心脏彩色多普勒超声检查可提高检出率及监测疗效,甲襞微循环检查及血清血管内皮素-1测定可能有助于早期判断SSc有无心脏损害。

Objective To evaluate the Clinical features with systemic sclerosis （SSc） heart damage and vascular en- dothelin - 1. Methods In 101 eases SSc patients nailfold miemcireulation examination and serum vascular endothelin - 1 deter- mination. Conducted a retrospective analysis of 45 cases of heart damage SSe clinical. Results SSc heart damage valve, myo- cardium, pericardium, conduction system involvement. SSc merged heart damage nailfold mieroeirculation pipe loop morphology integral, integral blood flow state loop weeks integral, the total score and the SSe heart damage group was significantly higher, the difference was statistically significant （P 〈0. 05）. Concurrent cardiac damage SSc ET- 1 levels in patients with the higher heart damage, the difference was statistically significant （P 〈 0. 05 ）. Conclusion SSc associated with cardiac damage ECG, cardiac Color Doppler ultrasound can improve the detection rate and monitoring the efficacy, the nailfold microcireulation exami- nation and serum vascular endothelin - 1 was measured to help determine whether heart damage.