热毒宁注射液治疗小儿手足口病的疗效

目的:评价热毒宁注射液治疗小儿手足口病的临床疗效。方法:收治手足口病患儿174例,随机分为治疗组88例和对照组86例。对照组给予5%葡萄糖注射液+利巴韦林10～15mg/(kg·日)静滴,1次/日,疗程5天;治疗组应用热毒宁注射液0.5～1ml/(kg·日),连续应用5天。比较两组在发热消退时间、疱疹消退时间、咽峡部红肿消退时间及总病程等方面的变化和差异。结果:治疗组发热消退时间、疱疹消退时间、咽峡部红肿消退时间及总病程等均较对照组明显缩短,差异有统计学意义(P<0.05)。结论:热毒宁注射液治疗小儿手足口病疗效显著,临床无明显不良反应。

Objective：To evaluate the efficacy of reduning injection in children with hand - foot - mouth disease. Methods： Totally 174 children with hand - foot - mouth disease were randomly divided into therapeutic group（88 cases） and control group （ 86 cases）. Children in therapeutic group were treated with reduning injection intervenously 0. 5 - 1 ml/（ kg · d ）, once a day for 5 days ; while the patients in control group were treated with ribavirin intervenously 10 ～ 15mg/ （kg · d） ,once a day for 5 days. The total course and disappearance time of fever,purpura, pharyngeal swelling, and the side effects were observed. Results： The disappearance time of fever, purpura, pharyngeal swelling and total course were shorter in the therapeutic group than those in the control group, the difference between the two groups was statistically significantly （ P 〈 O. 05 ）.Conclusions：The efficacy of reduning injection in children with hand - foot - mouth disease were proved, no side effect observed.