9例注射用阿莫西林钠致肾功能损害不良反应/事件分析

Retrospective Analysis of 9 Cases with Amoxicillin Sodium Injection-induced Acute Kidney Damage

目的分析注射用阿莫西林钠致严重肾损害不良反应病例报告,为临床安全合理用药提供参考。方法采用回顾性研究方法,对山东省药品不良反应监测中心2004～2011年收到的9例注射用阿莫西林钠致肾功能损害不良反应/事件报告进行分析评价。结果在9例不良反应/事件报告中,患者全部为女性;年龄在34～68岁之间,其中58～68岁之间为7例;均为超剂量使用;有5例患者同时合用了肾毒性药物;有6例在给药后的第2～3天即出现肾功能损害。结论应进一步加强注射用阿莫西林钠致肾功能损害的研究,规范临床用药,加强肾功能的监测。

Objective To analyze the adverse reaction case reports of amoxicillin sodium injection, and provide a reference for the safe and rational drug use in clinical practice. Methods A retrospective analysis was conducted for the 9 cases adverse drug reaction/event （ADR/ADE） reports by amoxicillin sodium injection induced acute kidney damage in Shandong collected during 2004-2011. Results The results showed that 9 cases of ADR/ADE were all female; between 34 and 68 years old; there were 7 cases between 58-68 years old; all the cases were overdosed; 5 patients were also combined the renal toxic drugs at the same time; 6 cases were found with renal damage 2 to 3 days after the administration. Conclusion It is very necessary to strengthen the study of amoxicillin sodium injection induced acute kidney damage, standardize the clinical drug use and enhance monitoring of renal function.