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GnRH-a在IVF垂体降调节中的应用 被引量：1

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摘要 1984年,促性腺激素释放激素激动剂(gonadotrophin releasing hormone agonist,GnRH-a)首次应用于体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)垂体降调节并且取得成功后,GnRH-a已被广泛应用于体外受精(IVF)垂体降调节中。GnRH-a有长效制剂(3.75 mg)和短效制剂(0.1mg)两种剂型,均可用于垂体降调节,两者临床效果无显著差异。由GnRH-a的不同用法而衍生出的长方案、短方案及超长方案、超短方案已被绝大多数IVF中心应用于控制性超排卵(controlled ovarian hyper-stimulation,COH)中。但对不同的患者如何采取不同的方案以取得满意的效果又可减少患者的经济负担,一直是学者们关心和研究的热点。
作者 付建华 林秀英 孙玉红
机构地区 吉林省人民医院生殖医学中心
出处 《中国实用医药》 2013年第4期249-251,共3页 China Practical Medicine
关键词 促性腺激素释放激素激动剂 垂体降调节 个体化
分类号 R714.8 [医药卫生—妇产科学]
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参考文献22

  • 1Porter RN, Smith W, Graft IL, et al. Induction of ovulation for in 2 vitro fertilization using buserelin and gonadotrophins, 1984,(8414): 1284-1285.
  • 2Cramer DW, Powers DR, Oskowitz SP, et aL Gonadotropin relea- sing hormone agonist use in assisted reproduction cycles : the influ- ence of long and short regimens on pregnancy rates. Fertil Sertil, 1999,72( 1 ) :83-88.
  • 3Hazout A, de Ziegler D, Cornel C, et al. Comparison of short 7 day and prolonged treatment with gonadotropin releasing hormone agonist desensitization for controlled ovarian hyperstimula-tion. Fertil Ser- til, 1993,59(3) :596-600.
  • 4Yim SF, Lok IH, Cheng LP, et aL Dose finding study for the use of long acting gonadotrophin releasing hormone analoges prior to o- varian stimulation for IVF. Hum Reprod,2001,16 (3) :492-494.
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  • 6Mijatovic V, Florijn E, Halim N, et al. Adenomyosis has no ad- verse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. Eur J Obstet Gynecol Repred Biol,2010,151 (1) :62-65.
  • 7Mohamed AM, Chouliaras S, Jones C J, et al. Live birth rate in fresh and frozen embryo transfer cycles in women with endometrio- sis. Eur J Obstet Gyneeol Reprod Biol,2011,156(2) :177-180.
  • 8Alviggic, Clarizia R, MoUA, et al. Outlook:who needs LH in ovar- ian stimulation? Reprod Biomed online,2006,12 (5) :599-607.
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二级参考文献14

  • 1Porter RN, Smith W, Craft IL,et al. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins [J]. Lancet, 1984,2(8414) : 1284-1285.
  • 2Janssens RM, Lambalk CB, Vermeiden JP, et al. Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study [J]. Hum Reprod, 2000, 15 (11) : 2333-2340.
  • 3Albuquerque LE, Saconato H, Maeiel MC. Depot versus daily administration of gonadotrophin releasing hormone agonist protocols for pituitary desensitization in assisted reproduction cycles [J]. Cochrane Database Syst Rev, 2005, ( 1 ): CD002808.
  • 4Janssens RM, Lambalk CB, Vermeiden JP, et al. Dosefinding study of triptorelin acetate for prevention of premature LH surge in IVF: a prospective, randomized, double-blind, placebocontrolled study. Hum Reprod, 2000, 15(11):2333-40.
  • 5Humaidan P, Bungum L, Bumgum M, et al. Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction wit h GnRH agonist down-regulation and recombinant FSH stimulation. Hum Reprod, 2002, 17(8):2016-21.
  • 6Poter RN, SmitW, Craft IL, et al. Induction of ovulation for in vitro fertilization using buserelin and gonadtrop ins. Lancet, 1984, 2(8414): 1284-5.
  • 7Hillier SG. Ovarian stimulation with recombinat gonadotrophins: LH as adjunct to FSH/Jacobs HS (ed.) The New Frontier in Ovulation Induction. Parthenon, UK: Carnforth, 1993:39-47.
  • 8Balasch J, Vidal E, Penarrubia J, et al. Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH. Hum Reprod, 2001, 16 (8): 1636-43.
  • 9Park JK, Clark R, Session DR, et al. Follicular recruitment is reduced in minimal stimulation for controlled ovarian hyperstimulation using purified human menopausal gonadotropin compared with follicle-stimulating hormone. Fertil Steril, 2009, 91(4): 1434-6.
  • 10Balasch J, Vidal E, Penarrubia J, et al. Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH. Hum Reprod, 2001, 16(8): 1636-43.

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中国实用医药
2013年 第4期

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