α-糜蛋白酶与沐舒坦在雾化吸入预防全麻术后患者呼吸道并发症的对照研究

目的:比较沐舒坦与α-糜蛋白酶两种药物在雾化吸入预防下腹部全麻术后患者呼吸道并发症的效果。方法:严格按照纳入标准选择150例下腹部手术患者,随机分为沐舒坦组和α-糜蛋白酶组,两组分别予以沐舒坦和α-糜蛋白酶雾化吸入,观察两组咳嗽、咳痰、声嘶、咽痛、支气管炎及药物不良反应的发生率。结果:两组咳痰、声嘶、咽痛、支气管炎及药物不良反应的发生率无差异(P>0.05),α-糜蛋白酶组咳嗽发生率低于沐舒坦组(P<0.05)。结论:在雾化吸入时,预防下腹部全麻术后患者呼吸道并发症α-糜蛋白酶效果优于沐舒坦。

Objective：To compare the efficacy of oL - chymotrypsin and ambroxol in aerosol inhalation for preventing respiratory tract complications in patients underwent surgery under general anesthesia. Methods ： 150 pa- tients underwent surgery under general anes- thesia were randomly assigned into two groups, one group patients inhaled o~ -chy- motrypsin by high flow oxygen while the oth- er group patients inhaled ambroxol. To ob- serve the incident rate of cough,expectora- tion, hoarse, pharyngalgia, bronchitis and ad- verse reaction in two groups. Results： No significant difference were found in incident rate of expectoration, hoarse, pharyngalgia, bronchitis or adverse reaction between the two groups（P 〉0.05） ,With regard to inci- dent rate of cough, the c~ - chymotrypsin group was lower than the ambroxol group. （P 〈 0.05 ）. Conclusion ： The efficacy of of - chymotrypsin in aerosol inhalation for pre- venting respiratory tract complication in pa- tients who underwent surgery under general anesthesiais is better than ambroxol.