摘要
心房颤动(房颤)是最常见的持续性心律失常,房颤总的发病率为0.4%,随着年龄增长房颤的发生率不断增加,75岁以上人群可达10%。房颤时心房激动的频率达300~600次/分,心跳频率往往快而且不规则。
参考文献7
-
1Reill JC,Hohl M,Oberhofer M,et al.Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterizedby structural remodeling[J].Cardiovasc Res,2010,87(3):485.
-
2Dud ley SC,H och NE,Mc Cann LA,et al.A tria lfib rillat ion increasesp roduction of superox ide by the left atrium and left atrial appendage:role of the NADPH and xanth ine ox idases[J].C irculation,2008,112:1266.
-
3Lpez B,Gonzlez A,Hermida N,et al.Role of lysy lox idase inm yocard ial fib ros is,from basic science to clin ical aspects[J].Am J Physiol Heart Circ Physiol,2010,10:1152.
-
4Kum agai K,Nakashima H,Urata H,et al.Effects of angioten sin II type 1 recep tor an tagon ist on electrical and stru ctura l rem odeling in atrial fib rillation[J].J Am Coll Cardiol,2008,41:2197.
-
5Tsai CT,Lai LP,Kuo KT,et al.Angioten sin II activates signal transdu cer and act ivators of t ranscript ion 3 via R ac1 in atria lm yocytes and f ibrob lasts:implication for the therapeu tic effect of statinin atrial structural remodeling[J].Circulation,2008,117(3):344.
-
6Pracyk JB,Tanaka K,Hegland DD,et al.A requ irem ent for the rac1 GTPase in the signal transdu ct ion pathw ay leading to card iacm yocyte hypertrophy[J].J Clin Invest,2008,102:929.
-
7Higuchi Y,Otsu K,Nishida K,et al.The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptos is signa-lregu lating kinase 1 and nuclear factor-B[J].J Biol Chem,2008,278:20770.
同被引文献29
-
1Tong L,Tergaonkar V. Rho protein GTPases and their interactions with NF κB :crossroads of in ammation and matrix biology [ J ]. Bio- sci Rep,.2014,34(3) :e00115.
-
2Dierkes R, Wamking K, Liedmann S, et al. The Rael Inhibitor NSC23766 exerts anti-Influenza virus properties by affecting the vi- ral polymerase complex activity [ J ]. PLoS One, 2014, 9 ( 2 ) : e88520.
-
3Gungur B, Gombos I, Crul T, et al. Rael participates in thermally induced alterations of the eytoskeleton, cell morphology and lipid rafts, and regulates the expression of Heat shock proteins in B16F10 melanoma Cells[ J]. PLoS ONE ,2014,9 (2) : e89136.
-
4Durrn RV, Hall MN. Regulation of TOR by small GTPases [ J ]. EMBO Rep,2012,13(2) :121-128.
-
5Woollard SM, Li H, Singh S, et al. HIV-1 induces cytoskeletal al- terations and Racl activation during monocyte-blood-brain barrier interactions modulatory role of CCR5 [ J]. Retrovirology ,2014,11 : 20.
-
6Van Helden SF, Anthony EC, Dee R, et al. Rho GTPase Expressionin Human Myeloid Cells [ J ]. PLoS One,2012,7 ( 8 ) : e42563.
-
7Bongmba OY, Martinez LA, Elhardt ME, et al. Modulation of den- dritic spines and synaptic function by Racl :Apossible link to Frag- ile X syndrome pathology [J].Brain Res ,2011 , 1399:79-95.
-
8Neill DR1, Wong SH, Bellosi A, et al. Nuocytes represent a new in- nate effector leukocyte that mediates typer2 immunity [ J ]. Nature, 2010,464 ( 7293 ) : 1367-1370.
-
9Juncadella IJ, Kadl A, Shal~a AK, et al. Apoptotic eell clearance by bronchial epithelial cells critically influences airway inflamma- tion[ J]. Nature,2013,493 (7533) :547-551.
-
10Eitel J, Meixenberger K, van Laak C, et al. Racl regulates the NLRP3 inflammasome which mediates IL-lbeta production in Chlamydophila pneumoniae infected human mononuclear cells. [ J]. PLoS ONE ,2012,7 ( 1 ) : e30379.
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-
1刘镇元,方海龙,温春花.免疫调节剂对反复哮喘患儿的干预效果[J].现代医院,2016,16(3):368-369. 被引量:1
-
2李玉轩.老年心房颤动合并缺血性脑卒中患者的临床特点及抗凝治疗效果[J].实用临床医药杂志,2020,24(6):113-115. 被引量:9
-
3曹海利.用华法林对心房颤动合并心力衰竭患者进行治疗的效果观察[J].当代医药论丛,2020,18(6):19-20. 被引量:2
-
4孙莉,荀平.华法林抗凝治疗对房颤患者的用药不良反应发生率、并发症发生率评估[J].临床医药文献电子杂志,2020,7(71):134-134.
-
5车飙,高艳,肖蕾,黄金莲.口腔溃疡相关因子的研究进展[J].日用化学工业,2021,51(9):881-889. 被引量:3
-
6吴琦玮,张莉,俞力,沈榕.EPB49在结直肠癌组织中表达水平及与患者预后的关系分析[J].湖南师范大学学报(医学版),2018,15(1):94-98.
-
1赵先帆.饮酒与房颤患者的严重心悸相关[J].心血管病防治知识,2012(10):34-35.
-
2陈浩.灭活Rac1能保护鼠肝以免缺血/再灌注损害[J].国外医学(外科学分册),2004,31(4):243-243.
-
3警惕恶性心律失常[J].长寿,2010(9):57-57.
-
4贾中伟.对心房颤动的四个认识误区[J].开卷有益(求医问药),2013(7):16-17.
-
5心律失常患者应注意什么[J].医药与保健,2008(9):38-39.
-
6相鹏,崇爱国,吴慧平.华法林对房颤合并糖尿病患者的安全性和疗效观察[J].全科医学临床与教育,2012,10(2):186-187.
-
7邢春玲.无创通气治疗顽固性左心衰竭临床效果观察[J].中国现代药物应用,2015,9(22):148-149. 被引量:1
-
8常怡勇.黄连素,一味良“心”药[J].养生保健指南(中老年健康),2016,0(6):51-51.
-
9周宇非,匡煜坤.无创正压通气在重症肺炎中的应用研究[J].中外医疗,2013,32(20):102-102. 被引量:1
-
10孙小伟.房颤治疗依从性差的危害[J].心血管病防治知识,2012(6):72-73. 被引量:2