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Racl在心房颤动中的作用研究进展 被引量:2

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摘要 心房颤动(房颤)是最常见的持续性心律失常,房颤总的发病率为0.4%,随着年龄增长房颤的发生率不断增加,75岁以上人群可达10%。房颤时心房激动的频率达300~600次/分,心跳频率往往快而且不规则。
作者 郝迎春
出处 《中国社区医师(医学专业)》 2013年第3期229-229,共1页
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参考文献7

  • 1Reill JC,Hohl M,Oberhofer M,et al.Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterizedby structural remodeling[J].Cardiovasc Res,2010,87(3):485.
  • 2Dud ley SC,H och NE,Mc Cann LA,et al.A tria lfib rillat ion increasesp roduction of superox ide by the left atrium and left atrial appendage:role of the NADPH and xanth ine ox idases[J].C irculation,2008,112:1266.
  • 3Lpez B,Gonzlez A,Hermida N,et al.Role of lysy lox idase inm yocard ial fib ros is,from basic science to clin ical aspects[J].Am J Physiol Heart Circ Physiol,2010,10:1152.
  • 4Kum agai K,Nakashima H,Urata H,et al.Effects of angioten sin II type 1 recep tor an tagon ist on electrical and stru ctura l rem odeling in atrial fib rillation[J].J Am Coll Cardiol,2008,41:2197.
  • 5Tsai CT,Lai LP,Kuo KT,et al.Angioten sin II activates signal transdu cer and act ivators of t ranscript ion 3 via R ac1 in atria lm yocytes and f ibrob lasts:implication for the therapeu tic effect of statinin atrial structural remodeling[J].Circulation,2008,117(3):344.
  • 6Pracyk JB,Tanaka K,Hegland DD,et al.A requ irem ent for the rac1 GTPase in the signal transdu ct ion pathw ay leading to card iacm yocyte hypertrophy[J].J Clin Invest,2008,102:929.
  • 7Higuchi Y,Otsu K,Nishida K,et al.The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptos is signa-lregu lating kinase 1 and nuclear factor-B[J].J Biol Chem,2008,278:20770.

同被引文献29

  • 1Tong L,Tergaonkar V. Rho protein GTPases and their interactions with NF κB :crossroads of in ammation and matrix biology [ J ]. Bio- sci Rep,.2014,34(3) :e00115.
  • 2Dierkes R, Wamking K, Liedmann S, et al. The Rael Inhibitor NSC23766 exerts anti-Influenza virus properties by affecting the vi- ral polymerase complex activity [ J ]. PLoS One, 2014, 9 ( 2 ) : e88520.
  • 3Gungur B, Gombos I, Crul T, et al. Rael participates in thermally induced alterations of the eytoskeleton, cell morphology and lipid rafts, and regulates the expression of Heat shock proteins in B16F10 melanoma Cells[ J]. PLoS ONE ,2014,9 (2) : e89136.
  • 4Durrn RV, Hall MN. Regulation of TOR by small GTPases [ J ]. EMBO Rep,2012,13(2) :121-128.
  • 5Woollard SM, Li H, Singh S, et al. HIV-1 induces cytoskeletal al- terations and Racl activation during monocyte-blood-brain barrier interactions modulatory role of CCR5 [ J]. Retrovirology ,2014,11 : 20.
  • 6Van Helden SF, Anthony EC, Dee R, et al. Rho GTPase Expressionin Human Myeloid Cells [ J ]. PLoS One,2012,7 ( 8 ) : e42563.
  • 7Bongmba OY, Martinez LA, Elhardt ME, et al. Modulation of den- dritic spines and synaptic function by Racl :Apossible link to Frag- ile X syndrome pathology [J].Brain Res ,2011 , 1399:79-95.
  • 8Neill DR1, Wong SH, Bellosi A, et al. Nuocytes represent a new in- nate effector leukocyte that mediates typer2 immunity [ J ]. Nature, 2010,464 ( 7293 ) : 1367-1370.
  • 9Juncadella IJ, Kadl A, Shal~a AK, et al. Apoptotic eell clearance by bronchial epithelial cells critically influences airway inflamma- tion[ J]. Nature,2013,493 (7533) :547-551.
  • 10Eitel J, Meixenberger K, van Laak C, et al. Racl regulates the NLRP3 inflammasome which mediates IL-lbeta production in Chlamydophila pneumoniae infected human mononuclear cells. [ J]. PLoS ONE ,2012,7 ( 1 ) : e30379.

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