901例女性人乳头瘤病毒感染状况及基因型分布的调查

A survey on the infection and genotype distribution of human papilloma virus of 901 female

目的探讨高低危型人乳头瘤病毒（human papilloma virus，HPV）在不同年龄段的感染情况，为防治宫颈癌、尖锐湿疣等HPV相关疾病提供理论依据。方法收集有HPV感染临床检测指征（宫颈炎、宫颈上皮内瘤变及宫颈癌）的女性标本901例，利用导流杂交基因芯片技术对阴道分泌物进行HPV分型检测。结果901例标本HPV阳性率为41．73％，其中单纯高、低危型HPV和高低危型HPV混合感染率分别为60．90％（229／376）、23．67％（89／376）和15．43％（58／376）；高危型HPV感染各个年龄段的感染率为26．39％～42．19％，低危型HPV感染各个年龄段的感染率为8．96％～39．19％，各型均呈现“U”型趋势。结论各年龄段主要感染型别为HPV16。低年龄段以高低危型HPV混合感染为主，≥55岁以单纯高危型HPV感染为主，单纯高危型HPV感染率随年龄增长而上升。

Objective To investigate the infection rate of high-risk and low-risk HPV in different age groups, and provide the theoretical foundation for preventing and treating the diseases caused by HPV, such as cervical cancer and condylomata acuminate. Methods Samples were collected from 901 female pa- tients with clinical indication for testing. The flow-through hybridization and gene chip were used to identifiy the subtypes. Results 376 cases were infected with HPV （41.73%） among the 901 patients. The positive rates of only high-risk and low-risk types of HPV were 60. 90% and 23.67% respectively. Positive rate of mixed infection with high and low-risk types HPV was 15.43%. The infection rates of high-risk type HPV in different age groups were from 26.39% to 42. 19%. The infection rates of low-risk type HPV in different age groups were from 8.96% to 39. 19%. Both the groups showed a ＂U＂ trend. Conclusions HPV16 infec- tion is the dominant type in different age groups. Low age groups were mainly mixed infected with high and low-risk HPV.≥55 years group was mainly infected with simple high-risk HPV; simple high-risk HPV in- fection rates rise with age.