1Thoreen CC, Sabatini DM. Rapamycin inhibits mTORC1, but not completely. J Autophagy, 2009, 5 (5) : 725-726.
2Esfandiarei M, Luo HL, Yanagawa B, et al. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. J Virol, 2004, 78 ( 8 ) : 4289- 4298.
5Jackson D, Killip MJ, Galloway CS, et al. Loss of function of the influenza A virus NS1 Protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase(PI3K). J Virology, 2010, 396( 1 ) : 94-105.
6Ehrhardt C, Ludwig S. A new player in a deadly game : influenza viruses and the Pi3K/Akt signaling pathway. J Cell Microbiology, 2009, 11(6) : 863-871.
7Hale BG, Kerry PS, Jackson D, et al. Struetura insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 Protein. J PNAS, 2010, 107(5) : 1954-1959.
8Peng L, Liang DY, Tong WY, et al. Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FKS06-binding protein 38 (FKBP38) and roTOR. J Biol Chem, 2010, 285(27): 20870-20881.
9Kriegs M, Burckstummer T, Himmelsbach K, et al. The hepatitis C virus non-structural NSSA protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem, 2009, 284 (41) : 28343-28351.
10George A, Panda S, Kudmulwar D, et al. Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F(elF4F) complex and up-regulates host translation ini- tiation machinery through elF4E-binding protein 1 inactivation. J Biol Chem, 2012, 287(7) : 5042-5058.
4Fresno Vara JA, Casado E, de Castro J, et al. PI3K/Akt signalling pathway and cancer[ J ]. Cancer Treat Rev ,2004,30(2 ):193-204.
5Eves EM,Xiong W, Bellaeosa A, et al. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuroal cell line[J]. Mol Cell Bio1,1998,18(4) :2143-2152,
6Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt -dependent cell survival by the tumor suppressor PTEN [ J ]. Cell, 1998,95 ( 1 ) :29-39.
7Zhou X,Tna MI Stone Hawthorne V,et al. Activation of the Akt/ mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers [ J ]. Clin Cancer Res ,2004, 10 ( 20 ) :6779-6788.
8Park CM,Park MJ,Kwak HJ,et al. Ionizing radiation enhancesmatrix metalloproteinase-2 secretion and invasion of glioma cells through src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways [ J ]. Cancer Res ,2006,66 ( 17 ) :8511-8519.
9Vicanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer [ J ]. Nat Rev Cancer, 2002, 2 ( 2 ) : 489-501.
10Dong Z, Huang C, Ma W. PI-3 kinase in signal transduction, cell transformation,and as a target for chemoprevention of cancer[ J]. Anticancer Res, 1999,19 (5 A) :3743-3748.
1Gitig DM, Koff A. Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors [ J]. Mol Biotechnol, 2001, 19(2) : 179-188.
2Van Dross R, Yao S, Westlake G, et al. Constitutively active K- cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-in- fected cells [J]. J Natl Cancer Inst, 2005, 97(9) : 656-666.
3Iwanaga R, Ozono E, Fujisawa J, et al. Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax [ J]. Oncogene, 2008, 27(42): 5635-5642.
4Saha A, Halder S, Upadhyay SK, et al. Epstein-Barr virus nucle- ar antigen 3C facilitates G1-S transition by stabilizing and enhan- cing the function of eyclin D1 [ J ]. PLoS Pathog, 2011, 7 (2) : e1001275.
5Nguyen DX, Westbrook TF, McCance DJ. Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phos- phatase during deregulation of cell cycle arrest [ J ]. J Virol, 2002, 76(2) : 619-632.
6Knight GL, Turnell AS, Roberts S. Role for Weel in inhibition of G2-to-M transition through the cooperation of distinct human papil- lomavirus type 1 FA proteins [ J]. J Virol, 2006, 80(15) : 7416- 7426.
7Goh WC, Manel N, Emerman M. The human immunodeficiency virus Vpr protein binds Cde25C: implications for G2 arrest [ J ]. Virology, 2004, 318( 1 ) : 337-349.
8Kamata M, Watanabe N, Nagaoka Y, et al. Human immunodefi- ciency virus type 1 Vpr binds to the N lobe of the Weel kinase do- main and enhances kinase activity for CDC2 [ J]. J Virol, 2008, 82(12) : 5672-5682.
9Elder RT, Yu M, Chen M, et al. HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Weel and Cdc25 [ J]. Virology, 2001, 287 ( 2 ) : 359 -370.
10Lingyun Li, Bin Gu, Feng Zhou, et al. Humanherpesvirus 6 suppresses T cell proliferation through induction of cell cyclearrest in infected cells in the G2/M phase [J]. J Virol, 2011, 85 ( 13 ) : 6774-6783.