农药毒菌锡的毒性研究

Study on the Toxicity of Organotin Fungicide － Fentin Hydroxide

本研究按照农药登记毒理学试验方法(GB15670－1995),对毒菌锡原药进行了大鼠急性经口毒性试验,蓄积性毒性试验,亚慢性(90天)混饲经口毒性试验,小鼠骨髓细胞微核率,小鼠睾丸初级精母细胞染色体畸变率试验,以及Ames试验和皮肤致敏试验.结果显示雌、雄大鼠急性经口毒性(LD50)分别为162、200mg／kg,蓄积系数≥1.亚慢性毒性试验结果显示最大无作用剂量为1．6mg／kg.小鼠骨髓细胞微核率,小鼠睾丸初级精母细胞染色体畸变率试验,以及Ames试验和皮肤致敏试验结果均为阴性.

Based on toxicological test methods of pesticides for registration, animal experiments of acute oral toxicity, accumulative toxicity, subchronic toxicity, dermal sensitization study, bone marrow cell micronucleus test, teticale cell chromosome aberration analysis and Ames test were carried out． For female rats the acute oral toxicity (LD50)was 162 mg／kg and 200 mg／kg for male rats． A accumulative ratio≥ 1 was determined on male rats． The maximum non effect level in subchronic experiment was 1．6 mg／kg． But it has obvious accumulative toxicity． Dermal sesitization experiment was negative． Non－mutagenicity was detected in mutagenic tests．