子宫内膜癌组织学类型与CEA、c-erbB-2表达

Histological types and CEA,c-erbB-2 expression of endometrial carcinomas

目的 :观察子宫内膜癌的组织学类型与CEA、c erbB 2表达 ,探讨其组织学发生。方法 :光镜观察组织学形态并进行分型 ,应用免疫组化S P法 ,对 94例子宫内膜癌进行单克隆抗体CEA和c erbB 2检测。结果 :子宫内膜样癌 6 1例 (6 4.8% ) ,腺棘癌 6例 (6 .3% ) ,腺鳞癌 8例 (8.4% ) ,浆液性乳头状腺癌 7例 (7.4% ) ,粘液性癌 5例 (5 .3% ) ,小细胞癌 4例 (4.2 % ) ,透明细胞癌和鳞癌各 1例 (1.6 % )。内膜癌各亚型中以粘液性癌、腺棘癌和腺鳞癌CEA表达较高 ,而内膜样癌阳性表达少 ,仅见腔缘阳性 ;c erbB 2在各型内膜癌中均有表达 ,差异无显著性 (P >0 .0 5 )。结论 :各型内膜癌均有不同程度的CEA和c erbB 2的表达 ,与组织学类型无关 ;子宫内膜癌的多种组织学类型来源是苗勒氏管上皮多向分化的结果。

?Objective:To observe the histological types and the expression of CEA and c erbB 2 in 94 cases of endometrial carcinoma, and to study its histogenesis. Methods:The histological types were observed routinely and classified. The expressions of CEA and c erbB 2 in 94 cases of endometrial carcinoma were studied immunohistochemically (S P methods). Results:According with histological qeature of the cases examined endometrial carcinoma were classified as endometroid carcinoma in 61 cases (64.8%), adenoacanthoma in 6 cases(6.3%), adenosquamous carcinoma in 8 cases (8.4%), serous papillary adenocarcinoma in 7 cases (7.4%) ,mucinous carcinoma in 5 cases (5.3%),small cell carcinoma in 4 cases (4.2%), clear cell carcinoma and squamous carcinoma in 1 cases (1.6%).CEA expressed diffusely in mucinous carcinoma, adenoacanthoma and adenosquamous carcinoma and expressed only at the edge of lumen in endometroid carcinoma; c erbB 2 expression was shown in all types of endometrial types of endometrial carcinoma. The difference in expression between the two markers was not significant ( P >0.05). Conclusions:CEA and c erbB 2 may express positively in all types of endometrial carcinoma in various degree with as correlation to the histological type. The difference in histological types originates from the multiple directional differentiation of Müllerian duct.