半乳糖凝集素-3和细胞角蛋白-19在桥本甲状腺炎合并微小乳头状癌不同组织中的表达

Expressions of Galectin-3 and Cytokeratin-19 in Different Tissues of Hashimoto Thyroiditis Complicated with Papillary Thyroid Microcarcinoma

目的探讨半乳糖凝集素-3（galectin-3，Gal-3）和细胞角蛋白．19（cytokeratin-19，CK-19）在桥本甲状腺炎（HT）合并微小甲状腺乳头状癌（PTMC）不同组织中的表达及其临床意义。方法收集25例HT合并良性结节患者（HT合并良性结节组）、25例PTMC患者（PTMC组）及25例HT合并PTMC患者（HT合并PTMC组）的肿瘤结节组织、距离肿瘤0．5cm以远的正常甲状腺组织及对侧叶正常甲状腺组织，采用免疫组织化学法检测不同组织中Gal-3和CK-19的表达。结果①PTMC组和HT合并PTMC组的结节组织中Gal-3和CK-19的表达阳性率均明显高于HT合并良性结节组（P〈0．05）。②HT合并良性结节组和HT合并PTMC组的对侧叶组织中Gal-3和CK-19的表达阳性率均明显高于PTMC组（P〈0．05）。③HT合并良性结节组和HT合并PTMC者的距肿瘤0．5cm组织中Gal-3和CK-19的表达阳性率均明显高于PTMC组（P〈0．05）。④在HT合并PTMC组的距肿瘤0．5cm组织中Gal-3和CK-19表达中阳性和强阳性率均分别明显高于HT合并良性结节组和PTMC组（P〈0．05）。结论①Gal．3和CK．19联合检测可作为鉴别甲状腺良、恶性肿瘤指征；②伴HT疾病中Gal．3和CK-19的表达水平明显高于不伴HT疾病的正常甲状腺组织中的表达情况，提示HT疾病易癌变；③Gal-3和CKo-19联合检测有助于HT恶性变倾向的判断和甲状腺癌的早期诊断，特别在其强阳性表达中应视为已恶变；④HT合并PTMC时．府扩女手术蒲隔，以行侧叶加对侧叶女部分切除或令叶切除为官．

Objective To explore the expressions tissues of Hashimoto thyroiditis （HT） complicated with pap of galectin-3 （Gal-3） and cytokeratin-19 （CK-19） illary thyroid microcarcinoma （PTMC） Methods in different The tumor tissue, 0. 5 cm near tumor tissue, and opposite lateral lobe thyroid tissue in 25 HT with benign nodus patients, 25 PTMC patients, and 25 HT with PTMC patients were collected. The expressions of Gal-3 and CK-19 in these tissues were detected by immunohistochemical methods. Results ①The positive rates of Gal-3 and CK-19 expressions in the tumor tissue of HT with PTMC patients and PTMC patients were significantly higher than those of HT with benign nodus patients （P〈0. 05）. ② The positive rates of Gal-3 and CK-19 expressions in the opposite lateral lobe thyroid tissue of HT with PTMC patients and HT with benign nodus patients were significantly higher than those of PTMC patients （P〈0. 05）.③ The positive rates of Gal-3 and CK-19 expressions in the 0. 5 cm near tumor tissue of liT with PTMC patients and HT with benign nodus patients were significantly higher than those of PTMC patients （P〈 0. 05）. ④ The middle and strong positive rates of Gal-3 and CK-19 expressions in the 0. 5 cm near tumor tissue of HT with PTMC patients were significantly higher than those of HT with benign nodus patients and the PTMC patients （P〈 0. 05）. Conclusions ① Gal-3 and CK-19 protein are helpful to differentiate the benign thyroid tumor and malignant one. ②The expressions of Gal-3 and CK-19 protein in patients with HT are clear higher than those in patients without HT that means the prognosis evaluation in HT canceration. ③ Gal-3 combined with CK-19 protein are help for early diagnosis, the pathogenesis and prognosis evaluation in thyroid cancer. The strong positive means canceration.④In HT with PTMC, it needs an operation therapy and a larger one, which is appropriate for lateral and opposite lobe partial resection or total resection.