血浆纤维蛋白原和D-二聚体检测在COPD抗凝治疗中的临床意义

Clinical significance of plasma fibrinogen and D-dimer detection in anticoagulation therapy of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)患者急性加重期及稳定期血浆中纤维蛋白原(Fg)和D-二聚体(D-D)的变化及其临床意义。方法对28例COPD急性加重期患者,30例COPD稳定期患者及30例健康体检者(对照组)的血浆Fg和D-D分别进行测定。结果 COPD患者急性加重期血浆Fg和D-D明显高于COPD稳定期患者及健康对照者,差异有统计学意义(P<0.05)。结论监测COPD患者血液中Fg和D-D水平,有助于临床医生及时了解COPD患者体内凝血状况,并为合理、及时使用抗凝剂提供依据,从而有助于改善患者临床预后,减少病死率。

Objective To explore the changes of plasma fibrinogen （Fg）and D-dimer（DD） in the patients with acute exacerbation and stable stage of chronic obstructive pulmonary disease （COPD） and their clinical significance. Methods 28 patients with acute exacerbation of COPD, 30 patients with stable stage of COPD and 30 cases as control were detected plasma Fbg and DD. Results Plasma Fg and DD in the patient＇s with acute exacerbation of COPD were significantly higher than those in the stable stage of COPD and the control group,the difference showing statistical significance（P〈0.05）. Conclusion Monitoring plasma levels of Fg and DD in the patients with COPD can help clinicians to understand the in vivo coagulation status of the patients with COPD and provide a basis for reasonable and timely use of anticoagulants ,which can improve the clinical prognosis and reduce the mortality.