广州管圆线虫性肺炎的病理学研究

EXPERIMENTAL STUDY ON PATHOLOGY OF ANGIOSTRONGYLUS CANTONENSIS PNEUMONIA

目的 探讨广州管圆线虫性肺炎的病理变化特征。方法 大白鼠感染管圆线虫后 ,用组织学、组织化学及电镜观察肺组织的形态改变。结果 成虫寄生于肺动脉内形成虫栓 ,虫卵及幼虫阻塞肺毛细血管形成异物肉芽肿结节。肺血管内弹力膜断裂 ,坏变性小动脉炎及内皮细胞呈弥漫性或簇状乳头状增生。肺部还可伴随支气管炎 ,肺炎及肺脓肿等改变。结论 实验性广州管圆线虫性肺炎的主要病变为成虫和虫卵的栓塞血管 ,血管的坏变和内皮细胞高度增生 ,成虫的栓塞 ,广泛的虫卵结节及伴发严重的肺脓肿是造成死亡的主要因素。

Aim To identify the pathological feature of experimental cantonensis pneumonia experimentaly Methods To observe the morphalogical changs in the lung of rats infected by A.cantonensis with the mechods of histology,histochemistry and ultrastructure Results Thrombus have formed by the adults worm parasitized in the lung artery Worm eggs and the first stage larva formed foreign granuloma node that block blood capillary in lung It caused pulmovascular internal elastic membrane fragmentation,necrotic small angiitis,and large artery endothelial cell diffuse or papillate proliferation There was also going with changes such as bronchitis,pneumonia and pulmonary abscess Conclusion The main pathological process in experimental A cantonensis pneumonia is adult worm and worm eggs blocking pulmovascular,Artery necrotizing and endothelial cell high proliferating Adult worm embolic infarction,diffuse eggs node and concomitant serious lung abscess is the major factor causing death