富于T细胞的大B细胞淋巴瘤

T-cell-rich Large B-cell Lymphoma

目的 探讨富于T细胞的大B细胞淋巴瘤的病理形态、预后和免疫组化的诊断意义。方法 对 3例富于T细胞的大B细胞淋巴瘤进行临床、组织病理和免疫组化分析 ,并复习文献。结果 3例中 2例女性 ,1例男性 ,平均年龄 5 2 7岁。 3例之肿瘤性大细胞L2 6阳性 ,背景小细胞UCHL 1阳性。富于T细胞的程度为 6 0 %～ 70 %。 1例见富于T细胞的大B细胞淋巴瘤与弥漫性大B细胞性淋巴瘤共存。

Objective To study the histopathologic features, prognosis and diagnostic significance of immunohistochemistry in T cell rich B cell lymphoma (TCRBCL). Methods Both clinicopathologic and immunohistochemical aspects of TCRBCL were analyzed in 3 cases. Results There were two female and one male. Their mean age was 52.7 years. Immunostainings showed that neoplastic large cells were L26+, with more than 60% UCHL1+ small lymphoid cells on background in all the cases. One patient was complicated by diffuse large B cell lymphoma. Conclusion TCRBCLs could be the morphological variants of different types of large B cell lymphomas.