骨肉瘤雄激素受体的表达及意义

Expression and significance of AR in osteosarcoma

目的 探讨雄激素受体 (AR)与骨肉瘤病理特征的关系及在骨肉瘤发病中的作用。 方法 应用免疫组化SP方法对 6 5例骨肉瘤石蜡包埋组织进行AR检测 ;骨肉瘤的病理分型与病理分级按刘子君法分类。 结果 (1)AR阳性率为 5 0 8% (33例 ) ;(2 )阳性颗粒分布于胞浆和胞核 ;(3)高分化组AR阳性率低 ,低分化组AR阳性率高 ,差异有显著性意义 (χ2 =4 16 4,P <0 0 5 ) ;(4)不同病理分型的AR阳性率无显著性差异 (χ2 =0 16 6 ,P >0 0 5 )。 结论 骨肉瘤组织中瘤细胞存在AR ,其阳性表达与肿瘤分化程度有关。

Objectives [WT5”BZ]To determine the relationship between AR and pathological characteristics of osteosarcoma and to investigate the potential role of AR in the pathogenesis of osteosarcoma. [WT5”HZ]Methods [WT5”BZ]AR in the samples of the paraffin embedded tissues from 65 cases of osteosarcoma was immunohistochemically detected by streptavidin/peroxidase (SP) method. The pathology of osteosarcoma was classified and graded according to Liu Zijun′s Classification. [WT5”HZ]Results [WT5”BZ]The positive rate of AR was 50 8%(33/65). The positive particles were distributed in the cytoplasm and nucleus. The positive rate of AR in osteosarcoma with higher grade of cell differentiation was lower than that in the tumor with lower one. There was no significant difference in different pathological type of osteosarcoma. [WT5”HZ]Conclusion [WT5”BZ]AR exists in osteosarcoma and its positive rate is related to the cell differentiation of osteosarcoma. [WT5”HZ]