肠出血性大肠埃希菌O104∶H4病原学及其防治研究进展

Advances in research on etiology and control of enterohaemorrhagic Escherichia coli O104:H4 infection

2011年5-7月在德国北部暴发一起肠出血性大肠埃希菌(enterohemorrhage,Escherichia coli,EHEC)O104:H4感染的疫情,该疫情从德国北部起始,很快就席卷整个德国并蔓延至欧洲、北美国家。EHECO104:H4是新世纪以来出现的又一新发传染病,其致病性强,传播速度快,引起全世界的关注。迄今中国尚无此病的报道,但在全球化的今天,了解并充分防范已成共识。据此,该文就EHEC的病原学、快速检测法、所引起的主要疾病发病机制及临床症状、预防措施等方面的研究进展进行综述。

There was an outbreak of enterohaemorrhagic Escherichia coli （EHEC） O104 ： H4 infection in Germany from May to August in 2011. It started from North Germany, soon swept across the whole country, and then spread to the rest of Europe and North America. EHEC O104 ： H4 infection is a new infectious disease occurring in the new century and has attracted worldwide attention due to its strong pathogenicity and fast transmission. So far the disease has not been reported in China, but with the globalization, it is necessary to understand and prevent the disease. This paper aims to review the advances in the research on EHEC O104 ： H4 in terms of etiology, rapid detection, pathogenesis and symptoms of associated diseases, and preventive measures.