三维适形放疗治疗早期非小细胞肺癌疗效分析

Analysis of Three Dimensional Conformal Radiation Therapy for Early Stage Non-small Cell Lung Cancer

目的分析三维适形放疗(3DCRT)治疗早期非小细胞肺癌(NSCLC)的疗效。方法 36例经病理组织学和(或)细胞学确诊的早期NSCLC患者接受3DCRT,分割剂量每次2～3 Gy,每周5次,总剂量60～75Gy,中位剂量68 Gy。靶区包括肿瘤原发灶及亚临床灶区。中位随访期46(14～68)个月。结果全组总有效率为92%,1、2、3、4、5 a局部控制率分别为71%、62%、49%、38%、26%,1、2、3、4、5 a生存率分别为70%、58%、46%、35%、22%,未出现Ⅲ级以上放射性肺炎和放射性食管炎。结论 3DCRT治疗早期NSCLC安全、有效,近期疗效满意,远期疗效需要进一步观察。

Objective To analyze the curative effect of three dimensional conformal radiation therapy （3DCRT） for early stage non-small cell lung cancer （NSCLC）. Methods Thirty six patients with early stage NSCLC diagnosed by pathology or cytology were treated with 3DCRT： 2 -3 Gy/fraction ,5 fractions/week, a total close of 60 Gy to 75 Gy,the median dose was 68 Gy. Primary tumor and subclinical focus were included in the clinical target volume. The median follow-up period was 46 （14-68） months. Results The efficiency rate was 92%. The 1-,2-,3-, 4-,5-year local control rate was 71% , 62% , 49% , 38 % , 26 % , respectively. The 1 -, 2-, 3-, 4-, 5-year survival rate was 70% ,58% ,46% ,35% ,22% ,respectively. None of the patients developed grade III or severe radiation pneumonia or radiation esophagitis. Conclusion 3DCRT is safe and effective for patients with early stage NSCLC, the short-term effect is satisfactory, the long-term result needs further follow-up.