1Leyland-Jones B. Trastuzumab: hopes and realities [ J ]. Lancet 0n- col,2002,3 ( 3 ) : 137 - 144.
2Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER,2-positive breast cancer [ J]. N Engl J Med, 2011,365 ( 14 ) : 1273 - 1283.
3Perez EA, Romond EH, Suman VJ. Four-year follow-up of trastu- zumab plus adjuvant Chemoth-erapy for operable human epidermal growth factor receptor 2-positive breast cancer:joint ana|ysis of data from NCCTG N9831 and NSABP B-31 [ J ]. J Clin Oncol, 2011,29 (25) :3366 - 3373.
4Krop IE,Beeram M, Modi S,et al. Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to pa- tients with HER2-positive metastatic breast cancer [ J ]J Clin On- col ,2010,28 ( 16 ) :2698 - 2704.
5Burris HA , Rugo HS,Vukelja S J, et al. Phase lI study of the anti- body drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 ( HER2 ) -positive breast cancer after prior HER2-directed therapy [ J ]. J Clin Onco1,2011,29 (4) : 398 - 405.
6Baselga J,Gelmon KA,Verma S,et al . Phase II trial of pertuzumaband trastuzumab in patients with human epidermal growth factor re- ceptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy [ J ]. J Clin Oncol, 2010,28 (7) : 1138 -1144.
7Baselga J, Cortes J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer [ J ]. N Engl J Med, 2012,366(2) :109 - 119.
8Somlo G,Martel CL,Lau SK,et al. A phase I/lI prospective,sin- gle arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage 1V HER-2 positive metastatic breast cancer[J]. Breast Canc- er Res Treat,2012,131 ( 3 ) : 899 - 906.
9Cfistofanilli M, Valero V, Mangalik A, et al. Phase II , randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer [ J ]. Clin Cancer Res,2010,16 (6) : 1904 - 1914.
10Dickler MN, Cobleigh MA, Miller KD, et al. Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast canc- er[J]. Breast Cancer Res Treat,2009,115( 1 ) :115 - 121.
