喉喑安片的干法制粒工艺优选

Optimization of Dry Granulation Technology for Houyin'an Tablets

目的:优选喉喑安片的干法制粒工艺。方法:采用L9(34)正交设计试验,选取轮轧压力、压轮转速、进料转速为考察因素,以多指标综合评分考察干法制粒的工艺条件;在25℃,90%RH条件下,考察制备的喉喑安片的引湿性。结果:最佳干法制粒工艺为A1B3C3,即轮轧压力4 MPa,压轮转速30 r.min-1,进料转速20 r.min-1,第10 d的引湿试验平均增重1.5%。结论:该制备工艺质量稳定,产品防潮性良好。

Objective：To optimize dry granulation technology of Houyin＇an tablets. Method： With wheel rolling pressure,wheel speed and feeding speed as investigation factors,L9（34） orthogonal test was used to optimize dry granulation technology conditions with muiti-index composite score as index;Under 25 ℃,90%RH conditions,hygroscopicity of prepared Houyin＇an tablets was investigated. Result： Optimum dry granulation technology was A1B3C3,that was the wheel rolling pressure of 4 MPa,pressure wheel speed 30 r·min-1,feeding speed of 20 r·min-1.On the tenth day,average increased weight of Houyin＇an tablets was 1.5% by hygroscopicity test. Conclusion： Quality of Houyin＇an tablets was stable with good moisture resistance,which was prepared by optimized technology.