川芎嗪联合醒脑静对放射性视神经病变视野及视觉诱发电位的影响

Changes of Visual Vield and VEP in Patients of Radiation-induced Optic Neuropathy Treated with Ligustrazine Combined with Xingnaojing Injection

目的:研究分析川芎嗪联合醒脑静对放射性视神经病变(RION)患者的临床疗效。方法:回顾性分析2003年6月至2012年3月RION 18例(32只眼),所有患者均给予川芎嗪注射液160 mg和醒脑静注射静脉20 mL静脉滴注,1次/d,2周1个疗程,2周后重复1个疗程,观察2周和6周的视力(VA)、视野平均光敏感度(MS)、视觉诱发电位(VEP)及视盘周围视网膜神经纤维层(RNFL)厚度。结果:视网膜光敏感度明显增加(P<0.01)、VEP P100波潜伏期明显缩短(P<0.01)、VEP P100波振幅明显提高(P<0.01),视力和视盘周围视网膜神经纤维层厚度则没有明显改善。结论:川芎嗪联合醒脑静能很好的改善RION的视野和VEP。

Objective：To assess the treatment methods of Ligustrazine combined with Xingnaojing injection to radiation-induced optic neuropathy （RION） patients. Method： A retrospective study, 32 eyes in 18 patients with RION from June 2003 to March 2012. All patients were treated with Ligustrazine injection 160 mg and Xingnaojing Injection 20 mL each day for two weeks, and repeated it after two weeks interval. The visual acuity（VA）,visual field（VF）,visual evoked potential（VEP） and peripapillary retinal nerve fiber layer（RNFL） thickness were evaluated after 2nd,6th week. Result： After 2 and 6 weeks, there were in increasing mean sensitivity（P〈0.01）, in shortening P100 latency （P〈0.01）, in improving VEP amplitude （P〈0.01） of the RION patients. But there weren＇t statistical changes of in VA and RNFL. Conclusion： Ligustrazine combined with Xingnaojing injection can improve the mean sensitivity and VEP of RION.