辅助生殖技术治疗后流产相关原因分析

Analysis on abortion-related causes after assisted reproductive technology treatment

目的:探讨辅助生殖技术(assisted reproductive technology,ART)治疗后流产的发生率及其相关因素。方法:回顾性分析2008年6月～2011年12月在郑州大学第三附属医院生殖医学中心接受ART治疗后获得临床妊娠的558例患者,比较流产组和分娩组之间的年龄、体重指数(BMI)、不孕年限、促性腺激素使用天数(Gn天数)和总量(Gn总量)、获卵数、移植胚胎数、孕囊数和基础内分泌之间的流产率。结果:流产率年龄>35岁组明显高于<35岁组(P<0.01);BMI≥25 kg/m2组高于BMI<25 kg/m2组(P<0.05);随着移植胚胎数的增加,多胎率和流产率均增加;流产组的基础PRL高于分娩组。结论:ART治疗后流产的发生可能与患者的年龄、BMI、移植胚胎数、基础PRL相关。

Objective： To explore the incidence rate of abortion and related factors after assisted reproductive technology （ART） treatment. Methods： A total of 558 patients who received ART treatment and got clinical pregnancy in the hospital from June 2008 to December 2011 were analyzed retrospectively, the age, body mass index （BMI）, duration time of infertility, usage time and total dose of gonadotropin, the numbers of retrieved oocytes, transferred embryos, and gestational sac, and abortion rates were compared between abortion group and delivery group. Results： The abortion rate in women more than 35 years old was statistically significantly higher than that in women less than 35 years old （P 〈 0. 01 ） ; the abortion rate in women with BMI ≥25 kg/m2 was statistically significantly higher than that in women with BMI 〈 25 kg/m2 （ P 〈0. 05 ） ; the incidences of polyembryony and abortion increased with the increase of number of transferred embryos; basic prolactin level in abortion group was higher than that in delivery group. Conclusion： Abortion after ART may be correlated with age, BMI, the number of transferred embryos, and basic prolactin level.