生长抑素联合奥美拉唑治疗非静脉曲张性上消化道大出血的疗效

Efficacy of Continuous Intravenous Infusion of Somatostatin Combined with Omeprazole in Treatmeat for Acute Nonvariceal Upper Gastrointestinal Heavy Bleeding

目的观察持续静脉输注生长抑素联合奥美拉唑治疗急性非静脉曲张性上消化道大出血的疗效。方法将70例急性非静脉曲张性上消化道大出血患者随机分为治疗组(35例)和对照组(35例),治疗组给予生长抑素750ug首次静推,继之以250ug/h持续静脉泵入,奥美拉唑40mg首次静推,继之以8mg/h持续静脉泵入;对照组奥美拉唑40mg首次静推,继之以8mg/h持续静脉泵入。结果治疗组的止血显效率为88.6%,明显高于对照组(68.7%)(P<0.01)。结论持续静脉输注生长抑素联合奥美拉唑与单用奥美拉唑相比,在治疗急性非静脉曲张性大上消化道出血中更有效。

Objective To observe the efficacy of continuous intravenous infusion of somatostatin combined with omeprazole in the treatmeat for acute nonvariceal upper gastrointestinal heavy bleeding.Methods 60 patients with acute nonvariceal upper gastrointestinal heavy bleeding were randomized divided into treatment group （n=30） and control group （n=30） .Patients in treatment group received somatostatin 750ug i.v. and then continuous intravenous pump at a rate of 250 ug/h and then were given intravenous omeprazole 40mg first,then continuous intravenous pump at arate of 8mg/h. Patients in control group were given intravenous omeprazole 40 mg first, and then continuous intravenous pump at arate of 8mg/h. Results The effective rate of hemostasis in treatment group was 88.6%, much higher than that in control group（68.7%,P〈0.01）.Conclusion Continuous intravenous infusion of somatostatin combined with omeprazole is more effective than intravenous infusion of omeprazole in controlling acute nonvariceal upper gastrointestinal heavy bleeding.