强化降脂治疗对急性冠脉综合征经皮冠状动脉介入治疗效果的影响研究

Study on effect of intensive lipid-lowering in acute coronary syndrome during percutaneous coronary interven- tion

目的探讨强化降脂治疗对急性冠脉综合征经皮冠状动脉介入治疗效果的影响。方法选取2011年1月至2012年8月我院收治的急性冠脉综合征患者160例，随机分为实验组和对照组，PCI术前1周，实验组采用80mg辛伐他汀治疗，对照组采用20mg辛伐他汀治疗。结果支架置入后实验组中TIMI血流0、1级例数均明显少于对照组，而TIMI血流3级例数均明显多于对照组（P〈0．05）；两组患者的TMPG-3、无复流情况差异有显著性（P〈0．05）。PCI后24h实验组患者的血清hs—CRP、ICAM和P选择素水平明显低于对照组（P〈0．05）。结论急性冠脉综合征患者于PCI术前接受强化他汀治疗可更有效地改善其心肌灌注，减轻心肌损伤。

Objective To discuss the effect of intensive lipid-lowering on acute coronary syndrome （ACS） during pereutaneous coronary intervention （PCI）. Methods 160 patients of ACS from Jan 2011 to Aug 2012 were divided into 2 groups. The experimental group used 80 mg Simvastatin while the control group used 20 mg Simvastatin 1 week before PCI. Results The cases of TIMI 0 and 1 grade of experimental group were lower than those of control group while the cases of TIMI 3 grade were more than those in control group （P〈0.05）. The diverse of state of TMPG-3 and no-reflow of two groups had significance （P〈0.05）. The levels of hs-CRP, ICAM and P-slectin of experiment group were lower than those of control group 24 h after PCI. Conclusion In- tensive statin therapy before PCI can effectively improve myocardial perfusion and decrease myocardial damage for patients of ACS.