抗病毒治疗患者治疗依从性及用药满意度调查

Study on the compliance and medication satisfaction in patients receiving antiviral therapy

目的了解抗病毒治疗患者的治疗依从性和用药满意度。方法选取2008年1月至2011年5月在解放军三。二医院青少年肝病诊疗与研究中心住院的慢性乙型肝炎和丙型肝炎进行抗病毒治疗的患者，对其遵医行为、用药治疗满意度和治疗依从性不佳的原因进行调查。结果在抗病毒治疗的乙、丙肝患者中，82．80％（361／436例）的患者能够完全遵医，其中91．86％（79／86例）的丙肝患者能够完全遵医，80．57％（282／350例）的乙肝患者能够完全遵医，丙肝患者遵医行为明显优于乙肝患者，两组比较，差异有统计学意义（χ2=6．1773，P〈0．05）；完全遵医的乙肝患者的用药满意度得分（58．38±9．17）低于丙肝患者的（59．62±9．81）分，两组比较，差异有统计学意义（t=-1．0501，P〈0．05）。结论抗病毒治疗患者的依从性和用药满意度不尽如人意，其主要原因是药物副作用、疗效欠佳、缺乏用药监管、对疾病的错误认知和态度。

Objective To investigate the compliance and medication satisfaction in patients who received antiviral therapy. Methods Chronic hepatitis B and hepatitis C patients who had antiviral therapy from January 2008 to May 2011 in Center of Diagnosis, Treatment and Research for Teenagers Liver disease, 302 Military Hospital of China were chosen, and their compliance, medication satisfaction and reasons of bad treatment compliance were investigated. Results Among chronic hepatitis B and hepatitis C patients who received antiviral therapy, 82.80% had good compliance, in which, 91. 86% of hepatitis C patients and 80.57% of hepatitis B had good compliance. Hepatitis C patients were better than hepatitis B patients in compliance, and the difference was statistically significant （X2 = 6. 177 3, P 〈 0.05 ）. The medication satisfaction of hepatitis B patients who had good compliance was lower than that of hepatitis C patients [ （58.38 ± 9.17） vs （ 59.62 ± 9.81 ） ] , and the difference was statistically significant （ t = - 1. 050 1, P 〈 0.05 ）. Conclusions Treatment compliance and medication satisfaction degree are not as good as expected in patients who receive antiviral therapy, which are due to side effects of drugs, low therapeutic efficacy, lacking of medication monitoring and mistaken understanding of the diseases.