泉州地区儿童病原菌分布及耐药特点研究

Research on distribution of children common pathogenic and characteristics of bacteria resistant in Quanzhou

目的研究泉州地区儿童常见病原菌分布及耐药特点,为临床合理选用抗菌药物提供依据。方法监测2011年度泉州市儿童医院与泉州地区综合医院临床分离细菌耐药状况,以Whonet 5.5软件进行数据分析,比较儿童与成人临床常见病原菌耐药性差异。结果儿童和成人MRSA的检出率分别为13.9%和43.5%;儿童患者大肠埃希菌和肺炎克雷伯菌对氨基糖苷类和喹诺酮类药物的耐药率要低于成人,对第三、四代头孢菌素的耐药率则高于成人。结论儿童患者常见病原菌分布和耐药特点与成人存在一定的差异,应持续地进行细菌耐药监测。

OBJECTIVE To research the distribution of children common pathogenic and characteristics of bacteria resistant in Quanzhou and provide the guidance for the clinical treatment. METHODS All of the bacterial susceptibility results from Children＇s Hospital of Quanzhou and General Hospital of Quanzhou from Jan 1 to Dec 31, 2011 were collected by unified protocol and the data were analyzed by software WHONET 5.5. To compare the drug resistance among common pathogens between Children and adults. RESULTS The incidences of meticiUin-resistant S. Aureus（MRSA） from children resistance to aminoglycoside and quinolones was lower than the adult rate, the resistance to the third and fourth generation cephalosporin was higher than the adult. CONCLUSION There are some differences between children and adults in distribution of common pathogenic and characteristics of bacteria resistant, bacterial resistance should be continuously monitored.