顺铂同步放疗在肺癌治疗中的毒性分析和剂量控制

Toxicity analysis and dose control of cisplatin combined with concurrent radiotherapy for lung cancer

目的研究不同剂量顺铂同步放疗治疗非小细胞肺癌(NSCLC)的疗效和毒副反应,为顺铂的剂量控制提供一定的依据。方法 63例患者随机分为顺铂高、中、低剂量3组,每组给予注射相应剂量顺铂,同时行常规放疗。观察各组的疗效和毒副反应以及生存质量。结果高、中、低剂量组的总有效率均高于70%,且各相比较,差异无统计学意义(P>0.05)。各剂量组顺铂的毒性反应主要表现为白细胞减少,恶心、呕吐,肾功能损害。且随着顺铂剂量的升高,毒副反应也逐步加大。结论低剂量顺铂同步放疗有较好近期疗效和生存质量,且毒副反应较低,建议临床选用低剂量的顺铂同步放疗对非小细胞肺癌进行治疗。

OBJECTIVE To evaluate the clinical efficacy and toxicity effects of cisplatin combined with concurrent radiotherapy for non-small cell lung cancer. Furthermore, it also provide a basis for cisplatin dose control. METHODS 63 patients were randomly divided into high, medium and low dose cisplatin groups, each group was given the injection of the appropriate dose cisplatin, while conventional radiotherapy were given. The efficacy, tox- icity and the quality of life were observed in each group. RESULTS The total effective rate were more than 70% in the high, medium and low dose cisplatin groups. The difference was not statistically significant （P 〉 0. 05 ）. The main clinical manifestations of toxicity mainly were leukopenia, nausea, vomiting and kidney dysfunction, which increased as the dose of cisplatin rose. CONCLUSION Low-dose cisplatin with concurrent radiotherapy showes the better clinical efficacy,lower toxicity, and the patient has a better quality of life. Which can be recommended for clinical use.