辅酶Q_(10)对小儿心肌炎的作用及心功能影响

The effect of coenzyme Q_(10) on the cardiac function of myocarditis Children

目的考察辅酶Q10对小儿心肌炎的作用及心功能影响。方法收集2009年5月至2011年6月在我院儿科就诊的82例病毒性心肌炎患儿,随机分组为两组:对照组42例和辅酶Q10治疗组40例,以及40例正常儿童作为正常对照组。比较治疗前后的心功能指标。结果与正常对照组比,对照组和辅酶Q10治疗组的左室舒张末期内径(LVEDd)、左室舒张末期容积(LVEDv)、左室收缩末期容积(LVESv)、左室每搏输出量(LVSv)、左室射血分数(LVEF)、左室收缩末期内径(LVESd)、左室短轴缩短率(LVFS)和心脏舒张功能二尖瓣舒张晚期血流速度峰值与二尖瓣舒张早期血流速度峰值比值(VA/VE)都有显著差异(P<0.05);对照组和辅酶Q10治疗组治疗前心功能参数无显著差异(P>0.05);治疗后,辅酶Q10治疗组LVSv(42±14mL与36±9mL)、LVEF(53%±3%与56%±3%)、LVFS(37±5%与34±7%)和VE/VA(0.60±0.13与0.58±0.21)显著降低(P<0.05)。结论辅酶Q10对病毒感染的心肌炎具有改善心功能的作用。

OBJECTIVE To investigate the effect of coenzyme Ql0 on the cardiac thnction of viral myocarditis ehildren. METHODS From May 2009 to June 2011,82 children patients with viral myocarditis enrolled in our hos- pital pediatric were randomly divided into 2 groups ：42 eases of control group and 40 patients of eoenzyme Q10 treatment group. And 40 eases of healthy children were collected as normal control group. The parameters of cardiac func- tion of myoearditis children were compared before and after treatment. RESULTS Compared with normal control group, left ventrieular end diastolic diameter（ LVEDd）, left ventrieular end-diastolic volume （LVEDv）, left ventricular end-systolic volume（LVESv） ,left ventrieular systolic volume （LVSv）, left ventrieular ejection fraction（ LVEF）, left ventrieular fractional shortening （LVFS） and VE/VA in control group and coenzyme Q10 treatment group were signif- ieantly different （P 〈 0. 05 ）. Control group and eoenzyme Q10 treatment group had no significant differences before treatment（P 〉0. 05）. LVSv （42 ±14mL vs 36 ±9mL） ,LVEF （53% ±3% vs 56% ±3% ） ,LVFS （37 ±5% vs 34 ±7% ） and VE/VA （0. 60 ±0. 13 vs 0. 58 ±0. 21 ） in eoenzyme Q10 treatment group were significantly lower than control group after treatment（P 〈 0. 05）. CONCLUSION Coenzyme Q10 has a significant role in improving heart function of viral myoearditis.