嗜酸性粒细胞性食管炎

Eosinophilic esophagitis

嗜酸性粒细胞性食管炎是一种免疫/抗原介导的慢性食管炎症,以食管黏膜嗜酸性粒细胞浸润为主及食管功能障碍相关症状为临床病理特点.其发病机制尚未明确,普遍认为系由IgE和非IgE联合介导引起的变态反应.其诊断主要依据典型的临床表现及食管组织病理学改变,并排除胃食管反流病(gastroesophageal reflux disease,GRED)及其他可引起食管黏膜嗜酸性粒细胞浸润等疾病.其治疗方法主要包括饮食调节、药物治疗、食管扩张等.

Eosinophih＇c esophagitis （EoE） represents a chronic, immune/antigen-mediated inflammatory esophageal disease characterized clinicopathologically by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. The pathogenesis of EoE is incompletely understood but is generally considered to be related to IgE-and non-IgE-mediated hypersensi- tivity. The diagnosis of EoE relies mainly on typical clinical presentations, esophageal pathological changes, and exclusion of gastroesophageal reflux disease （GRED） and other conditions that cause esophageal eosinophilia. Management options include dietary modifications, pharmacological therapy, and endoscopic dilation.