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SPARC蛋白及其在胃癌中的研究进展

Progress in understanding role of SPARC protein in gastric cancer
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摘要 SPARC(secreted protein,acidic and rich in cyst-eine)蛋白是一种富含半胱氨酸(Cys)的酸性分泌蛋白,编码SPARC蛋白的基因定位于人类染色体5q31.3-q32,包含10个外显子,全长25.9kb,为单拷贝基因,高度保守,在各种生物中有超过70%的氨基酸序列同源.在与组织修复有关的纤维母细胞和内皮细胞以及在部分具有侵袭性的恶性肿瘤中呈高度表达.胃癌,在我国的发病率及死亡率均较高,其高死亡率与肿瘤的侵袭和转移密切相关,SPARC蛋白在胃癌组织中存在异常表达,SPARC在胃癌中是促进还是抑制作用可以说尚存在争议.本文主要就SPARC蛋白及其在胃癌中的研究进展作一综述. SPARC is a cysteine-rich secretory protein that is highly conservative and shares 〉70% amino acid sequence homology across all kinds of living organisms. The single-copy gene encoding the SPARC protein is located on human chromosome 5q31.3-q32, consists of 10 exons, and has a full length of 25 900 bp. SPARC protein is mainly expressed in tissue repair-related fibroblasts and endothelial cells, and high expression of SPARC protein has been noted in some aggressive malig- nant tumors. The incidence and mortality of gastric cancer are high in China, and the high mortality is closely related with tumor invasion and metastasis. SPARC protein is abnormally expressed in gastric carcinoma, and there is still controversy over the role of SPARC in gastric carcinoma. In this paper we review recent progress in understanding the role of SPARC protein in gastric cancer.
作者 王小霞 杨明 张艳桥
机构地区 哈尔滨医科大学附属第三医院内八科
出处 《世界华人消化杂志》 CAS 北大核心 2013年第5期409-414,共6页 World Chinese Journal of Digestology
关键词 SPARC蛋白 胃癌 研究进展 SPARC protein Gastric cancer Researchprogress
分类号 R735.2 [医药卫生—肿瘤]
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参考文献49

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二级参考文献33

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世界华人消化杂志
2013年 第5期

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