摘要
目的:考查薏苡仁油灌胃的急性毒性、皮肤刺激性和直肠刺激性作用。方法:严格依据国家食品药品监督管理局2005年颁布的《药物研究技术指导原则》进行试验。结果:薏苡仁油对小鼠灌胃的最大给药量为40mL.kg-1或32.8 g.kg-1,薏苡仁油对家兔完整皮肤或破损皮肤均未见有刺激性作用,对家兔直肠亦未见有刺激性作用。结论:常规口服薏苡仁油是安全的,并且其外用亦无皮肤刺激性和直肠刺激性,外用也安全。
Objective : To examine the acute toxicity and irritation in skin and rectum of Coix Seed Oil. Method : The study was followed closely to The Principle of Drug Research Technical Guidance ( edition 2005 ) issued by the State Food and Drug Administration. Results : The maximal oral dose on mice of Coix Seed Oil was 40 mL·kg^-1 or 32.8 g ·kg^-1 , and it had no irritation in rectum and normal or damaged skin of rabbits. Conclusion : Routine oral administration of Coix Seed Oil is safe, and it has no irritation in skin and rectum, and the external use of Coix Seed Oil is safe as well.
出处
《辽宁中医药大学学报》
CAS
2013年第3期39-40,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
薏苡仁油
急性毒性
刺激性
皮肤
直肠
Coix Seed Oil
acute toxicity
irritation
skin
rectum