清热凉血膏塌渍疗法对活动期强直性脊柱炎患者血清中IL-1及TNF-α的影响

Influence of Collapse Stains Treatment with Qingre Liangxue Paste on IL-1 and TNF-α in Serum in Treatment of Active Stage of Ankylosing Spondylitis

目的:观察清热凉血膏塌渍疗法治疗活动期强直性脊柱炎(ankylosing spondylitis,AS)的临床疗效及对外周血清中白细胞介素-1(Interleukin-1,IL-1)和肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的影响。方法:60例AS患者按照就诊先后顺序采用随机数字法分为2组,对照组(30例)给予美洛昔康分散片及柳氮磺吡啶片治疗,治疗组(30例)在对照组基础上加用清热凉血膏塌渍治疗,比较2组治疗后的总体疗效及IL-1和TNF-α水平的变化。结果:治疗组总有效率为86.67%,对照组仅为66.67%,2组总有效率比较差异有显著性(P<0.01)。治疗后2组IL-1及TNF-α的表达水平与治疗前比较均有明显下降(P<0.01),但治疗组的下降程度更优于对照组,2组比较差异有显著性(P<0.05)。结论:清热凉血膏塌渍治疗活动期AS疗效显著,降低外周血清中IL-1和TNF-α的表达水平可能是其抗炎镇痛的作用机制之一。

Objeetive ： To observe the clinical efficacy of collapse stains treatment with Qingre Liangxue Paste and its effeetions on the contents of Interleukin-1 （ [L-1 ）and Tumor necrosis factor-（x （ TNF-cx ） in peripheral serum in the treatment of active stage of ankylosing spondyfitis （ AS ）. Methods ： 60 cases of patients with AS were randomly divided into two groups, the control group （ 30 cases ）were treated with Meloxieam Dispersible Tablets and Sulfasalazine Tablets, the treatment group （ 30 cases ）were treated by collapse stains treatment with Qingre Liangxue Paste on the basis of the control group.The overall effieacy and the changes of IL-1 and TNF- a were compared between the two groups after the treatment. Results ： The total effective rate of the treatment group was 86.67%, while in the control group it was only 66.67%, the total effective rates had signifieant differences （P〈0.01）.The expression levels of IL-1 and TNF-a of the two groups were decreased significantly compared with those before treatment （P〈0.01）.However, the degree of decline in the treatment group was better than that in the control group （ P〈0.05 ）. Conehusion ： Collapse stains treatment with Qingre Liangxue Paste has significant effect in the treatment of AS, reducing the expression levels of IL-1 and TNF-a in peripheral serum may be one of the mechanisms of its anti- inflammatory analgesic.