急性心肌梗死早期血浆降钙素基因相关肽、血清丙二醛和梗死面积的研究

Studies on plasma calcitonin gene related peptide,serum malonyldial dehyde and the area of myocardial infarction during early acute myocardial infarction.

目的 :探讨急性心肌梗死 (AMI)早期血浆降钙素基因相关肽 (CGRP)、血清丙二醛 (MDA)和心肌梗死面积之间的相互关系。方法 :通过结扎家兔左冠状动脉前降支 (LAD)制成AMI动物模型 ,检测血浆CGRP和血清MDA的动态变化 ,并检测心肌梗死面积。结果 :家兔AMI即刻及AMI后 1、 3、 5、 6小时与结扎LAD前相比 ,血浆CGRP及血清MDA均升高 (P <0 0 5或P <0 0 1)。CGRP峰值与MDA峰值和心肌梗死面积无相关 ,MDA峰值与心肌梗死面积呈正相关 (r=0 7915 ,P <0 0 1)。结论 :AMI早期脂质过氧化反应是加重心肌损害、使心肌梗死面积扩展的重要因素 。

Objective:To evaluate the relationship among plasma Calcitonin gene related peptide(CGRP),serum malonyldialdehyde(MDA) and the area of myocardial infarction during early acute myocardial infarction(AMI).Methods:The animal model of AMI was established in rabbits.The left anterior descending branch(LAD) of rabbit coronary artery were ligated and plasma CGRP,serum MDA and the area of myocardial infarciton were measured.Results:At 0,1,3,5,6 hours after AMI,the levels of plasma CGRP and serum MDA were higher than those of pre ligation.There were significant differences( P <0 05 or P <0 01).The peak value of CGRP had no correlation with that of MDA and the area of myocardial infarction.The peak value of MDA had positive correlation with the area of myocardial infarction( P <0 05 or P <0 01).Conclusion:During the early period of AMI,lipid super oxigenative reaction is an important factor in aggravating the myocardial damage and increasing the area of myocardial infarction.The increase of CGRP,however,is probably one of compensatory protective elements of the ischemic myocardium.