摘要
目的研究炎症因子单核苷酸多态性与中国2型糖尿病患者牙周炎易感性的关系。方法解放军第306医院口腔中心和糖尿病中心分别对120例单纯2型糖尿病患者、110例2型糖尿病伴发牙周炎患者进行调查,内容包括年龄、性别、全身病史、牙周病史、病程、吸烟史等,通过聚合酶链式反应--限制性片段长度多态性方法进行白细胞介素细胞因子-1β+3594基因位点单核苷酸多态性分析。结果实验组和对照组的年龄、性别等一般资料数据均衡检验无差异。基因多态性分析表明,实验组IL-1β+3954 C等位基因的频率较对照组无显著差异无统计学意义。结论 IL-1β+3954等位基因与中国人2型糖尿病患者的牙周炎易感性无显著关系。
Objective To investigate the possible relationship between polymorphism and the periodontitis with type 2 diabetics. Methods A total of 120 diabetics and 110 diabetics with periodontitis were enrolled in this study. Documented information included patient age, gender, medical history findings, periodontal history and use of tobacco products. Single nucleotide polymorphisms （SNPs） at interleukin-1 （ IL-1 ） 13 ＋ 3954 were analyzed by standard polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. Results The frequency of IL-113 ＋ 3954 C gene type was not significantly increased in periodontitis group compared to controls. Conclusion IL-113 ＋ 3954 polymorphism was not related to periodontitis susceptibility in Chinese Type 2 diabetes mellitus.
出处
《北京口腔医学》
CAS
2013年第1期33-36,共4页
Beijing Journal of Stomatology
基金
全军科学技术研究"十一五"计划专项课题(06Z003)
