谷氨酰胺在胃肠道术后患者全胃肠外营养中的疗效评价

THE EFFECT OF GLUTAMINE ON TOTAL PARENTERAL NUTRITION IN THE POSTOPERATIVE GASTROIN TESTINAL SURGERY

目的:探讨在胃肠术后予加入谷氨酰胺的TPN的疗效。方法:32例胃肠道手术患者随即均分为对照组和Gln组,对两组病人胃肠功能恢复情况、术前术后蛋白质合成、氮平衡及等情况进行比较。结果:Gln组患者的并发症发生率及住院时间均较对照组低,并有显著性差异(p<0.05);同时,肠功能恢复时间Gln组(58.7±8.7)h短于对照组(60.3±6.7)h,但两组间差异无统计学意义;两组术后12d血清白蛋白、前白蛋白均有回升,但对照TPN组均明显低于Gln组,差异有统计学意义(P<0.05);术后第8d Gln组氮平衡的改善明显优对照组(P<0.05)。结论:加用谷氨酰胺的TPN的疗效是有利于改善胃肠道术后患者营养状况和促进胃肠功能的恢复。

Objective：To evaluate the effect of Glutamine on total parenteral nutrition（TPN） in post gastrointestinal surgery. Meth- ods：32 patients operation after performed with gastrointestinal surgery were randomly divided into Group Gin and Control Group. Con- ventional TPN were administrated in the Control Group, and Group Gin were administrated with conventional TPN pins glutamine. In- testinal function, serum albumin and nitrogen balance were accessed between two groups after treatment. Results：The occurrence of postoperative complication and hospitalization duration in Group Gin were fewer than those in the Control group（ P 〈 0. 05） ;The gastro- intestinal function recovery time for the Group Gin was shorter than the Control group（58.7 ±8.7h vs 60.3 ± 6.7h）, but significant differences were not between the 2 groups; the levels of serum albumin and pre - albumin elevated on the 12th day after operation with those of the Control group increased more slowly, significant differences were noted between the 2 groups （ P 〈 0. 05） ; Nitrogen balance in the Gin group was more significantly than the Control group on the 8th day after operation （P 〈 0.05 ）. Condution：TPN adjuncted with glutamine is more favourable on recovery of the nutritional status and gastrointestinal function in patients after gastrointemal surgery.