吡喹酮治疗对日本血吸虫病人抗幽门螺杆菌抗体的影响

EFFECTS OF PRAZIQUANTEL TREATMENT ON HELICOBACTER PYLORI ANTIBODY IN PATIENTS INFECTED SCHISTOSOMA JAPONICUM

目的 探讨吡喹酮治疗对日本血吸虫病患者血清抗幽门螺杆菌 H p Ig G水平的影响。方法 利用 H p全菌抗原对流行区 94例日本血吸虫病人治疗前后血清抗 H p Ig G进行检测。结果 治疗后 3、6个月 ,H p感染阳性率分别为 73.4%和70 .2 % (治疗前为 75 .5 % ) ,H p Ig G抗体水平分别为 0 .71± 0 .30和 0 .6 5± 0 .2 1(治疗前为 0 .80± 0 .2 3) ,对照组均有轻度升高。各年龄组 H p感染阳性率和血清 H p Ig G水平均随治疗进展而降低 ,其中 0～ 2 0岁年龄组血清 H p Ig G下降最快。血清抗H p Ig G和同期对应的日本血吸虫 31/ 32 k Da(Sj31/ 32 ) Ig G抗体平均水平及阴转值之间高度相关 (治疗后 3个月 r分别为 0 .85和 0 .6 5 ,治疗后 6个月 r分别为 0 .85和 0 .5 0 )。结论 日本血吸虫病人经吡喹酮治疗后 H p感染阳性率及血清 H p Ig G水平降低 ,日本血吸虫与 H p感染高度相关 ,血吸虫可能作为 H p感染的危险因素之一。

Aim\ To study the effects of praziquantel treatment on the level of Helicobacter pylori(Hp) antibody in patients infected Schistosoma japonicum.Methods\ The whole cell antigen of Hp was used to detect the Hp IgG antibody in 94 cases of sera from the patients before and after praziquantel treatment.Results\ The positive Hp infection rate was 73.4% and 70.2% respectively (75.5% before treatment) after treatment for 3 and 6 months.The level of Hp IgG was 0.71±0.30 and 0.65±0.21(0.80±0.23 before treatment)respectively.The Hp positive rate and the level of Hp IgG declined with the process of treatment in all age groups,but the Hp IgG level dropped the most quickly in the age group of 0~20.The level and the dropped value of Hp IgG were related to that of Sj31/32 IgG(0.85 and 0.65,0.80 and 0.50 after treatment for 3 and 6 months).Conclusion\ The results indicated that the praziquantel treatment can reduce the positive rate and the level of Hp IgG in patients of Schistosoma japonicum.There was a significant correlation between Schistosoma japonicum and Hp infection.Schistosoma japonicum might be one of the risk factors of Hp infection.