女性SLE患者血清性激素水平研究

Study on serum levels of sex hormones in female patients with SLE

为了探讨性激素在 SLE发病中的作用，我们采用放射免疫法检测了 20例女性 SLE患者血清睾酮 (T)、游离睾酮 (FT)、二氢睾酮 (DHT)、脱氢表雄酮 (DHEA)、雌二醇 (E2)、孕酮 (Pr)和泌乳素 (PRL)水平。结果发现患者血清 T、 FT、 DHT、 DHEA、 Pr明显低于正常对照， PRL明显高于正常对照 (P< 0.05)， E2无显著差异 (P >0.05)；未使用皮质类固醇治疗的患者血清雄激素水平也显著降低 (P< 0.05)。提示性激素异常在 SLE的发病中起了一定的作用。

To investigate the role of sex hormones in the pathogenesis of SLE, the serum levels of testosterone(T)、 free testosterone(FT)、 dihydrotestosterone(DHT) dehydroepiandrosterone(DHEA)、 estradiol(E2)、 progesterone(Pr) and prolactin(PRL) were measured in 20 female patients with SLE and 10 normal controls by radioimmunoassay. We found that serum levels of T、 FT、 DHT、 DHEA and Pr in SLE patients were significantly lower than those in the controls, the level of PRL was significantly increased(P< 0.05)； E2 was not significantly different from the controls (P >0.05)； patients not treated with corticosteroid showed decreased level of androgen(P< 0.05). It suggests that abnormal levels of sex hormones may play a role in the pathogenesis of SLE.