阿昔洛韦与伐昔洛韦预防频发性生殖器疱疹复发效果对比分析

Comparative Analysis of Recurrent Genital Herpes Recurrence Frequency of Acyclovir and Valacyclovir Prevention

目的探讨阿昔洛韦与伐昔洛韦2种抗病毒药物在进行频发性生殖器疱疹复发预防时的效果。方法选取来该院确症为频发性生殖器疱疹患者62例为研究对象,随机分成实验组和对照组,其中实验组服用伐昔洛韦,患者每次服用伐昔洛韦剂量为500mg,初始3个月2次/d,第4以及第5个月1次/d,到第6个月病患隔日服用1次,对于对照组,让患者每次服用阿昔洛韦剂量为400mg,2次/d,共服用6个月。比较两组复发次数、半年内复发率、脱落细胞排毒状况、头晕以及乏力不良反应的发生率等指标。结果在使用2种药物治疗之后,各个指标与病患治疗前相比,差异有统计学意义(P<0.05),并且状况变好了,并且实验组各个指标与对照组相比,差异有统计学意义(P<0.05)并且状况变好了。结论使用伐昔洛韦抗病毒药物比阿昔洛韦这种抗病毒药物更能预防频发性生殖器疱疹复发,能够有效降低频发性生殖器疱疹复发次数以及生殖器部位的无症状排毒。

Objective To investigate both acyclovir and valacyclovir antivirals during when the frequency of recurrent genital herpes recurrence prevention effect. Methods To the hospital to ensure disease frequency in patients with recurrent genital herpes 62 patients were randomly divided into the experimental group and the control group, the experimental group taking valacyclovir patients each taking Laval celecoxib Lowe dose of 500 mg, the initial three months 2 times/d, 4 and 5 months l/d, taking a patient the next day to 6 months for the control group, were each taking acyclovir dose of 400 mg, 2 times/d, taking a total of six months. Were compared relapse frequency, rate of relapse within six months, the incidence of exfoliated cells detox situation, dizziness and fatigue adverse indicators. Results After the treatment of the two drugs, each index compared with patients before treatment, the difference was statistically significant （P〈0.05）, and the situation becomes better, and the various indicators of the experimental group compared with the control group, the difference was statistically significance （P〈0.05）, and the situation changed for the better. Conclusion Valacyclovir antivirals more than acyclovir antiviral drugs, prevention can effectively reduce the frequency of recurrent genital herpes recurrence of asymptomatic shedding frequency of relapse frequency of recurrent genital herpes and genital area.