26例新疆维吾尔族恶性黑素瘤病理分析

Analysis on pathological features of malignant melanoma in Xinjiang uygur

目的:分析新疆维吾尔族恶性黑素瘤的病理学特征。方法:收集26例新疆维吾尔族恶性黑素瘤,采用HE染色和免疫组化标记,进行病理分析。结果:恶性黑素瘤的组织结构及病理形态复杂多样性,以多种细胞类型和组织形态混合存在为主要特征,细胞类型可分为:上皮样细胞型、梭形细胞型、小痣样细胞型、气球样细胞型、混合型。免疫组化标记瘤细胞表达HMB-45、S-100、Ki-67、Vim-entin、Melan-A分别为90%、100%、100%、90%、96%。结论:恶性黑素瘤临床表现复杂,其诊断及鉴别诊断主要依靠病理学、免疫组化检查。

Objective： To analyze the pathological features of malignant melanoma of Xinjiang uygnr. Methods： the pathological features were analyzed after HE staining and immunohistochemistry in 26 patients with malignant melanoma. Results： The histopathological structures and morphological characteristics of malignant melanoma were complex. The main features of melanoma under light microscopy showed a variety of histological features, including epithelioid cell type, spindle cell type, nevus- like eel[ type, hyloeyte cell type and mixed cell type. The immuno- histochemistry showed that the positivity rates of HMB - 45, S - 100, Ki - 67, Vimentin, Melan - A were 90%, 100% ,100% ,90% and 96% respectively. Conclusion： The melanoma has a variety of clinical manifestations and the diagnosis mainly depends on histopathological and immunohistoehemistry findings.