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胸腺上皮细胞的发育分化及其分子调控 被引量：2

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摘要 T细胞在胸腺中发育成熟依赖特殊的微环境,而胸腺上皮细胞(TECs)是微环境中最重要的成分之一。TECs主要分为皮质上皮细胞(cTECs)和髓质上皮细胞(mTECs),分别介导胸腺细胞的阳性选择和阴性选择过程。cTECs和mTECs来源于共同的胸腺上皮干细胞(TEPCs),经过一系列发育过程,最终分化为功能及表型成熟的TECs。TECs发育分化过程除受到自身内在基因如转录因子Foxn1和Aire的调控以外,还需要与间质细胞、胸腺细胞相互作用,接受外源信号如TNFR家族成员RANK、CD40和LTβR信号的调节,这些信号尤其对mTECs的发育至关重要。而成纤维细胞生长因子(FGFs)和Wnt通路则对TECs的扩增和功能维持非常重要。本文综述了TECs发育分化过程以及参与调控该过程的信号分子通路。
作者 孙丽娜 赵勇
机构地区 中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第3期314-319,共6页 Chinese Journal of Cellular and Molecular Immunology
基金 国家重点基础研究发展计划(973)资助(2010CB945301) 国家自然科学基金(C81130055) 中科院知识创新工程重要方向项目(YSC-X2-YW-R-238)
关键词 胸腺上皮细胞 Foxn1 AIRE TNFR NF-κB FGFS Wnt
分类号 R392.12 [医药卫生—免疫学]
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共引文献10

同被引文献23

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细胞与分子免疫学杂志
2013年 第3期

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